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Fulcrum Therapeutics
FULC

122 hedge funds and large institutions have $374M invested in Fulcrum Therapeutics in 2025 Q2 according to their latest regulatory filings, with 24 funds opening new positions, 34 increasing their positions, 46 reducing their positions, and 19 closing their positions.

New
Increased
Maintained
Reduced
Closed

874% more call options, than puts

Call options by funds: $6.27M | Put options by funds: $643K

152% more capital invested

Capital invested by funds: $148M → $374M (+$226M)

26% more first-time investments, than exits

New positions opened: 24 | Existing positions closed: 19

5.62% more ownership

Funds ownership: 95.16% → 100.78% (+5.6%)

4% more funds holding

Funds holding: 117 → 122 (+5)

26% less repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 46

Holders
122
Holders Change
+5
Holders Change %
+4.27%
% of All Funds
1.61%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.03%
New
24
Increased
34
Reduced
46
Closed
19
Calls
$6.27M
Puts
$643K
Net Calls
+$5.62M
Net Calls Change
+$5.51M

Top Buyers

Rank Fund Capital Flow
1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$8.5M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$7.16M
3
Goldman Sachs
Goldman Sachs
New York
+$3.96M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$3.19M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
+$2.66M

Top Sellers

Rank Fund Capital Flow
1
NCM
Nantahala Capital Management
Connecticut
-$2.86M
2
ACM
ADAR1 Capital Management
Texas
-$2.34M
3
BlackRock
BlackRock
New York
-$1.77M
4
Renaissance Technologies
Renaissance Technologies
New York
-$1.73M
5
EAM
Exome Asset Management
New York
-$1.31M
Name Holding Trade Value Shares
Change 		Change in
Stake
SSA
26
Schonfeld Strategic Advisors
New York
$1.41M +$1.09M +204,400 New
CCM
27
Catalio Capital Management
New York
$1.3M -$74K -13,835 -7%
Citadel Advisors
28
Citadel Advisors
Florida
$1.14M -$1.11M -208,022 -56%
PCM
29
Prelude Capital Management
New York
$985K -$263K -49,078 -26%
BFM
30
Boothbay Fund Management
New York
$973K +$438K +81,845 +137%
Bank of New York Mellon
31
Bank of New York Mellon
New York
$943K -$35.2K -6,588 -5%
FT
32
Fiduciary Trust
Massachusetts
$939K – – –
UBS Group
33
UBS Group
Switzerland
$930K +$339K +63,285 +88%
American Century Companies
34
American Century Companies
Missouri
$911K +$46.2K +8,638 +7%
Wellington Management Group
35
Wellington Management Group
Massachusetts
$870K +$676K +126,402 New
N
36
Nuveen
North Carolina
$858K -$151K -28,269 -18%
Barclays
37
Barclays
United Kingdom
$771K +$158K +29,606 +36%
SFI
38
Susquehanna Fundamental Investments
Pennsylvania
$768K -$209K -39,061 -26%
Simplex Trading
39
Simplex Trading
Illinois
$752K +$569K +106,339 +3,514%
Millennium Management
40
Millennium Management
New York
$727K +$348K +65,001 +160%
Susquehanna International Group
41
Susquehanna International Group
Pennsylvania
$684K +$185K +34,650 +53%
BCM
42
Bridgeway Capital Management
Texas
$671K – – –
Jacobs Levy Equity Management
43
Jacobs Levy Equity Management
New Jersey
$636K -$295K -55,184 -37%
MAM
44
Martingale Asset Management
Massachusetts
$626K +$487K +91,015 New
DekaBank Deutsche Girozentrale
45
DekaBank Deutsche Girozentrale
Germany
$616K – – –
Commonwealth Equity Services
46
Commonwealth Equity Services
Massachusetts
$574K – – –
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$573K -$30.7K -5,743 -6%
Two Sigma Advisers
48
Two Sigma Advisers
New York
$565K -$1.05M -195,700 -70%
RC
49
RBF Capital
California
$554K – – –
Renaissance Technologies
50
Renaissance Technologies
New York
$540K -$1.73M -322,600 -80%
1
2
3 4 5

FULC Hedge Fund Activity: Q2 2025 in Review

122 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Fulcrum Therapeutics (FULC) for Q2 2025, worth a combined $374M — up 152% from $148M a quarter earlier.

Buyers outnumbered sellers: 24 funds opened new FULC positions and 19 closed out — a net gain of 5 holders — while 34 added to existing stakes and 46 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $8.5M. The largest seller was Nantahala Capital Management, cutting an estimated $2.86M.

  • 122 institutional investors held Fulcrum Therapeutics (FULC) as of Q2 2025, up from 117 in Q1 2025.
  • Funds reported $374M of Fulcrum Therapeutics stock for Q2 2025, up 152% quarter-over-quarter.
  • 24 funds opened new Fulcrum Therapeutics positions in Q2 2025 and 19 closed out, a net change of +5 holders.
  • The largest Fulcrum Therapeutics buyer in Q2 2025 was Adage Capital Partners, an estimated $8.5M added.
  • The largest Fulcrum Therapeutics seller in Q2 2025 was Nantahala Capital Management, an estimated $2.86M sold.

Based on aggregated 13F filings for Q2 2025.