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Fulcrum Therapeutics

122 hedge funds and large institutions have $374M invested in Fulcrum Therapeutics in 2025 Q2 according to their latest regulatory filings, with 24 funds opening new positions, 34 increasing their positions, 46 reducing their positions, and 19 closing their positions.

New
Increased
Maintained
Reduced
Closed

874% more call options, than puts

Call options by funds: $6.27M | Put options by funds: $643K

152% more capital invested

Capital invested by funds: $148M → $374M (+$226M)

26% more first-time investments, than exits

New positions opened: 24 | Existing positions closed: 19

5.62% more ownership

Funds ownership: 95.16%100.78% (+5.6%)

4% more funds holding

Funds holding: 117122 (+5)

26% less repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 46

Holders
122
Holders Change
+5
Holders Change %
+4.27%
% of All Funds
1.61%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.03%
New
24
Increased
34
Reduced
46
Closed
19
Calls
$6.27M
Puts
$643K
Net Calls
+$5.62M
Net Calls Change
+$5.51M
Name Holding Trade Value Shares
Change
Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$70.4M
TCM
2
TCG Crossover Management
California
$36.1M
SCM
3
Suvretta Capital Management
New York
$35M +$82.9K +15,506 +0.3%
Adage Capital Partners
4
Adage Capital Partners
Massachusetts
$31.6M +$8.5M +1,589,000 +53%
BlackRock
5
BlackRock
New York
$30.1M -$1.77M -331,674 -7%
NCM
6
Nantahala Capital Management
Connecticut
$29.5M -$2.86M -534,394 -11%
Vanguard Group
7
Vanguard Group
Pennsylvania
$21.6M -$395K -73,935 -2%
Dimensional Fund Advisors
8
Dimensional Fund Advisors
Texas
$9.44M -$184K -34,412 -2%
Balyasny Asset Management
9
Balyasny Asset Management
Illinois
$9.21M +$7.16M +1,338,214 New
State Street
10
State Street
Massachusetts
$8.38M -$182K -34,074 -3%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$8.21M -$205K -38,237 -3%
D.E. Shaw & Co
12
D.E. Shaw & Co
New York
$8.1M +$3.19M +596,050 +103%
Goldman Sachs
13
Goldman Sachs
New York
$7.87M +$3.96M +740,936 +184%
WP
14
Woodline Partners
California
$6.18M
Northern Trust
15
Northern Trust
Illinois
$4.21M -$157K -29,411 -5%
Acadian Asset Management
16
Acadian Asset Management
Massachusetts
$3.87M +$1.17M +218,819 +64%
Point72 Asset Management
17
Point72 Asset Management
Connecticut
$3.43M +$2.66M +498,219 New
Invesco
18
Invesco
Georgia
$3.24M +$2.06M +384,566 +448%
EAM
19
Exome Asset Management
New York
$3.06M -$1.31M -244,188 -35%
IC
20
Ikarian Capital
Texas
$2.95M +$1.22M +228,425 +114%
Charles Schwab
21
Charles Schwab
California
$2.67M +$34.4K +6,423 +2%
Connor, Clark & Lunn Investment Management (CC&L)
22
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$2.36M +$668K +124,798 +57%
Morgan Stanley
23
Morgan Stanley
New York
$2.16M +$154K +28,811 +10%
Bessemer Group
24
Bessemer Group
New Jersey
$1.98M
Deutsche Bank
25
Deutsche Bank
Germany
$1.92M -$3K -561 -0.2%

FULC Hedge Fund Activity: Q2 2025 in Review

122 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Fulcrum Therapeutics (FULC) for Q2 2025, worth a combined $374M — up 152% from $148M a quarter earlier.

Buyers outnumbered sellers: 24 funds opened new FULC positions and 19 closed out — a net gain of 5 holders — while 34 added to existing stakes and 46 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $8.5M. The largest seller was Nantahala Capital Management, cutting an estimated $2.86M.

  • 122 institutional investors held Fulcrum Therapeutics (FULC) as of Q2 2025, up from 117 in Q1 2025.
  • Funds reported $374M of Fulcrum Therapeutics stock for Q2 2025, up 152% quarter-over-quarter.
  • 24 funds opened new Fulcrum Therapeutics positions in Q2 2025 and 19 closed out, a net change of +5 holders.
  • The largest Fulcrum Therapeutics buyer in Q2 2025 was Adage Capital Partners, an estimated $8.5M added.
  • The largest Fulcrum Therapeutics seller in Q2 2025 was Nantahala Capital Management, an estimated $2.86M sold.

Based on aggregated 13F filings for Q2 2025.