Fulcrum Therapeutics
FULC
172 hedge funds and large institutions have $763M invested in Fulcrum Therapeutics in 2025 Q4 according to their latest regulatory filings, with 59 funds opening new positions, 43 increasing their positions, 49 reducing their positions, and 16 closing their positions.
269% more first-time investments, than exits
New positions opened: 59 | Existing positions closed: 16
230% more call options, than puts
Call options by funds: $8.87M | Put options by funds: $2.69M
54% more capital invested
Capital invested by funds: $496M → $763M (+$267M)
33% more funds holding
Funds holding: 129 → 172 (+43)
25.18% more ownership
Funds ownership: 99.44% → 124.62% (+25%)
0% more funds holding in top 10
Funds holding in top 10: 2 → 2 (0)
12% less repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 49
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
B
Braidwell
Stamford,
Connecticut
|
+$28.9M |
| 2 |
Point72 Asset Management
Stamford,
Connecticut
|
+$24.4M |
| 3 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$19.8M |
| 4 |
FTM
First Turn Management
Del Mar,
California
|
+$19.3M |
| 5 |
SCM
Suvretta Capital Management
New York
|
+$12M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RCM
RA Capital Management
Boston,
Massachusetts
|
-$42.5M |
| 2 |
Royal Bank of Canada
Toronto,
Ontario, Canada
|
-$10.1M |
| 3 |
Adage Capital Partners
Boston,
Massachusetts
|
-$7.45M |
| 4 |
Balyasny Asset Management
Chicago,
Illinois
|
-$4.89M |
| 5 |
NCM
Nantahala Capital Management
New Canaan,
Connecticut
|
-$3.84M |
FULC Hedge Fund Activity: Q4 2025 in Review
172 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Fulcrum Therapeutics (FULC) for Q4 2025, worth a combined $763M — up 54% from $496M a quarter earlier.
Buyers outnumbered sellers: 59 funds opened new FULC positions and 16 closed out — a net gain of 43 holders — while 43 added to existing stakes and 49 trimmed.
The largest buyer was Braidwell, adding an estimated $28.9M. The largest seller was RA Capital Management, cutting an estimated $42.5M.
- 172 institutional investors held Fulcrum Therapeutics (FULC) as of Q4 2025, up from 129 in Q3 2025.
- Funds reported $763M of Fulcrum Therapeutics stock for Q4 2025, up 54% quarter-over-quarter.
- 59 funds opened new Fulcrum Therapeutics positions in Q4 2025 and 16 closed out, a net change of +43 holders.
- The largest Fulcrum Therapeutics buyer in Q4 2025 was Braidwell, an estimated $28.9M added.
- The largest Fulcrum Therapeutics seller in Q4 2025 was RA Capital Management, an estimated $42.5M sold.
Based on aggregated 13F filings for Q4 2025.