|
1
|
T. Rowe Price Investment Management
Baltimore,
Maryland
|
$343M
|
+$279M
|
+14,727,667
|
+524%
|
|
|
2
|
Janus Henderson Group
London,
|
$272M
|
-$16.2M
|
-857,783
|
-6%
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$219M
|
+$27.6M
|
+1,455,151
|
+15%
|
|
|
4
|
|
$219M
|
+$29.5M
|
+1,555,929
|
+16%
|
|
|
5
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$179M
|
–
|
–
|
–
|
|
|
6
|
State Street
Boston,
Massachusetts
|
$131M
|
+$27M
|
+1,423,828
|
+27%
|
|
|
7
|
Fidelity Investments
Boston,
Massachusetts
|
$129M
|
+$22.1M
|
+1,168,005
|
+22%
|
|
|
8
|
FCPM III Services
Naarden,
Netherlands
|
$107M
|
–
|
–
|
–
|
|
|
9
|
Adage Capital Partners
Boston,
Massachusetts
|
$101M
|
+$30.6M
|
+1,618,000
|
+46%
|
|
|
10
|
Orbis Allan Gray
Hamilton,
Bermuda
|
$93.9M
|
+$90.9M
|
+4,801,928
|
New
|
|
|
11
|
TCG Crossover Management
Palo Alto,
California
|
$90.3M
|
–
|
–
|
–
|
|
|
12
|
|
$69.4M
|
+$3.5M
|
+184,664
|
+5%
|
|
|
13
|
Siren LLC
Greenwich,
Connecticut
|
$68.5M
|
-$23.2M
|
-1,226,233
|
-26%
|
|
|
14
|
Perceptive Advisors
New York
|
$68M
|
+$55.6M
|
+2,938,500
|
+544%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$63.8M
|
+$7.5M
|
+395,824
|
+14%
|
|
|
16
|
Armistice Capital
New York
|
$63.6M
|
+$3.52M
|
+185,708
|
+6%
|
|
|
17
|
Frazier Life Sciences Management
Palo Alto,
California
|
$61.7M
|
+$8.24M
|
+434,977
|
+16%
|
|
|
18
|
Deep Track Capital
Greenwich,
Connecticut
|
$51.8M
|
+$12.3M
|
+650,000
|
+33%
|
|
|
19
|
Vivo Capital
Palo Alto,
California
|
$51.1M
|
–
|
–
|
–
|
|
|
20
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$45.5M
|
+$17.5M
|
+925,702
|
+66%
|
|
|
21
|
|
$44.7M
|
+$7.25M
|
+382,976
|
+20%
|
|
|
22
|
Sofinnova Investments
Menlo Park,
California
|
$44.1M
|
+$24M
|
+1,268,333
|
+129%
|
|
|
23
|
|
$43.1M
|
-$2.12M
|
-112,000
|
-5%
|
|
|
24
|
|
$42.5M
|
–
|
–
|
–
|
|
|
25
|
Franklin Resources
San Mateo,
California
|
$39.2M
|
+$11.5M
|
+608,108
|
+43%
|
|
