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Denali Therapeutics

222 hedge funds and large institutions have $1.85B invested in Denali Therapeutics in 2025 Q1 according to their latest regulatory filings, with 35 funds opening new positions, 74 increasing their positions, 81 reducing their positions, and 34 closing their positions.

New
Increased
Maintained
Reduced
Closed

65% more call options, than puts

Call options by funds: $848K | Put options by funds: $515K

4.71% more ownership

Funds ownership: 88.89%93.6% (+4.7%)

3% more first-time investments, than exits

New positions opened: 35 | Existing positions closed: 34

0% less funds holding

Funds holding: 223222 (-1)

9% less repeat investments, than reductions

Existing positions increased: 74 | Existing positions reduced: 81

29% less capital invested

Capital invested by funds: $2.61B → $1.85B (-$758M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
222
Holders Change
-1
Holders Change %
-0.45%
% of All Funds
2.98%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
35
Increased
74
Reduced
81
Closed
34
Calls
$848K
Puts
$515K
Net Calls
+$333K
Net Calls Change
-$267K
Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$188M -$1.63M -85,289 -0.6%
Baillie Gifford & Co
2
Baillie Gifford & Co
United Kingdom
$164M -$4.29M -223,891 -2%
Vanguard Group
3
Vanguard Group
Pennsylvania
$160M -$4.24M -221,473 -2%
Wellington Management Group
4
Wellington Management Group
Massachusetts
$155M +$29.9M +1,561,647 +16%
Fidelity Investments
5
Fidelity Investments
Massachusetts
$101M -$11.6M -606,392 -8%
UBS AM
6
UBS AM
Illinois
$92M +$61M +3,184,042 +89%
Temasek Holdings
7
Temasek Holdings
Singapore
$72.8M
Capital Research Global Investors
8
Capital Research Global Investors
California
$64.8M -$13.6M -712,074 -13%
State Street
9
State Street
Massachusetts
$60.6M -$1.61M -84,216 -2%
T. Rowe Price Associates
10
T. Rowe Price Associates
Maryland
$59.4M +$25.1M +1,308,619 +43%
CM
11
Crestline Management
Texas
$56.6M -$2.87M -150,000 -3%
BBA
12
Baker Bros. Advisors
New York
$50.7M
AllianceBernstein
13
AllianceBernstein
Tennessee
$42.9M -$3.09M -161,255 -5%
Norges Bank
14
Norges Bank
Norway
$41.4M +$38M +1,981,998 +186%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$41.3M +$1.95M +101,893 +3%
Marshall Wace
16
Marshall Wace
United Kingdom
$29.8M +$7.66M +399,685 +22%
Dimensional Fund Advisors
17
Dimensional Fund Advisors
Texas
$28.6M +$4.71M +245,820 +13%
Goldman Sachs
18
Goldman Sachs
New York
$22.7M +$11.8M +614,555 +58%
Millennium Management
19
Millennium Management
New York
$20.3M +$20.9M +1,088,844 +269%
Fisher Asset Management
20
Fisher Asset Management
Washington
$18.6M +$11M +572,460 +72%
Morgan Stanley
21
Morgan Stanley
New York
$17M +$469K +24,463 +2%
CCM
22
Camber Capital Management
Massachusetts
$17M -$19.2M -1,000,000 -44%
Citadel Advisors
23
Citadel Advisors
Florida
$15.9M +$6.51M +339,772 +41%
Northern Trust
24
Northern Trust
Illinois
$15.4M -$1.33M -69,345 -6%
Bank of New York Mellon
25
Bank of New York Mellon
New York
$15M -$2.67M -139,095 -11%