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Denali Therapeutics

221 hedge funds and large institutions have $1.81B invested in Denali Therapeutics in 2025 Q1 according to their latest regulatory filings, with 36 funds opening new positions, 73 increasing their positions, 80 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more ownership

Funds ownership:

more first-time investments, than exits

New positions opened: | Existing positions closed:

less funds holding

Funds holding:

9% less repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 80

31% less capital invested

Capital invested by funds: $2.61B → $1.81B (-$800M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
221
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$848K
Puts
$515K
Net Calls
Net Calls Change

Top Buyers

1 +$43.3M
2 +$21.2M
3 +$17.8M
4
Millennium Management
Millennium Management
New York
+$14.8M
5
Squarepoint
Squarepoint
New York
+$8.68M
Name Holding Trade Value Shares
Change
Change in
Stake
MCM
101
MAI Capital Management
Ohio
$633K
P8IP
102
Pier 88 Investment Partners
California
$611K
Walleye Capital
103
Walleye Capital
New York
$600K
ERSOT
104
Employees Retirement System of Texas
Texas
$595K
Skandinaviska Enskilda Banken (SEB)
105
Skandinaviska Enskilda Banken (SEB)
Sweden
$588K
GCM
106
Graham Capital Management
Connecticut
$585K
Victory Capital Management
107
Victory Capital Management
Texas
$566K
KOCAA
108
Knights of Columbus Asset Advisors
Connecticut
$548K
Zurich Cantonal Bank
109
Zurich Cantonal Bank
Switzerland
$540K
Prudential Financial
110
Prudential Financial
New Jersey
$525K
Handelsbanken Fonder
111
Handelsbanken Fonder
Sweden
$521K
Pathstone Holdings
112
Pathstone Holdings
New Jersey
$521K
ASRS
113
Arizona State Retirement System
Arizona
$505K
Two Sigma Advisers
114
Two Sigma Advisers
New York
$480K
Teacher Retirement System of Texas
115
Teacher Retirement System of Texas
Texas
$474K
State Board of Administration of Florida Retirement System
116
State Board of Administration of Florida Retirement System
Florida
$465K
ProShare Advisors
117
ProShare Advisors
Maryland
$455K
DIA
118
Dana Investment Advisors
Wisconsin
$437K
Envestnet Asset Management
119
Envestnet Asset Management
Illinois
$427K
Creative Planning
120
Creative Planning
Kansas
$416K
EAM
121
Erste Asset Management
Austria
$398K
CUAMC
122
China Universal Asset Management Company
China
$396K
PA
123
Profund Advisors
Maryland
$379K
VIM
124
VELA Investment Management
Ohio
$378K
CWM
125
CIBC World Markets
New York
$375K