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Denali Therapeutics

221 hedge funds and large institutions have $1.81B invested in Denali Therapeutics in 2025 Q1 according to their latest regulatory filings, with 36 funds opening new positions, 73 increasing their positions, 80 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more ownership

Funds ownership:

more first-time investments, than exits

New positions opened: | Existing positions closed:

less funds holding

Funds holding:

9% less repeat investments, than reductions

Existing positions increased: 73 | Existing positions reduced: 80

31% less capital invested

Capital invested by funds: $2.61B → $1.81B (-$800M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
221
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$848K
Puts
$515K
Net Calls
Net Calls Change

Top Buyers

1 +$43.3M
2 +$21.2M
3 +$17.8M
4
Millennium Management
Millennium Management
New York
+$14.8M
5
Squarepoint
Squarepoint
New York
+$8.68M
Name Holding Trade Value Shares
Change
Change in
Stake
Two Sigma Investments
76
Two Sigma Investments
New York
$1.39M
RPAM
77
Rhenman & Partners Asset Management
Sweden
$1.36M
State of New Jersey Common Pension Fund D
78
State of New Jersey Common Pension Fund D
New Jersey
$1.27M
Mirae Asset Global ETFs Holdings
79
Mirae Asset Global ETFs Holdings
Hong Kong
$1.21M
Franklin Resources
80
Franklin Resources
California
$1.13M
DFCM
81
Dark Forest Capital Management
Puerto Rico
$1.1M
State of Wisconsin Investment Board
82
State of Wisconsin Investment Board
Wisconsin
$1.09M
D.E. Shaw & Co
83
D.E. Shaw & Co
New York
$1.06M
IIM
84
INTECH Investment Management
Florida
$1.05M
Wells Fargo
85
Wells Fargo
California
$1.05M
MIM
86
MetLife Investment Management
New Jersey
$1.02M
Tudor Investment Corp
87
Tudor Investment Corp
Connecticut
$987K
TC
88
TwinBeech Capital
New York
$979K
New York State Common Retirement Fund
89
New York State Common Retirement Fund
New York
$955K
DekaBank Deutsche Girozentrale
90
DekaBank Deutsche Girozentrale
Germany
$935K
CCIA
91
Campbell & Co Investment Adviser
Maryland
$927K
Thrivent Financial for Lutherans
92
Thrivent Financial for Lutherans
Minnesota
$924K
Janus Henderson Group
93
Janus Henderson Group
United Kingdom
$888K
CF
94
Corebridge Financial
Texas
$828K
HSBC Holdings
95
HSBC Holdings
United Kingdom
$779K
GC
96
Guggenheim Capital
Illinois
$762K
YIH
97
Y-Intercept (HK)
Hong Kong
$745K
VOYA Investment Management
98
VOYA Investment Management
Georgia
$693K
IIM
99
Ironwood Investment Management
Massachusetts
$670K
SG Americas Securities
100
SG Americas Securities
New York
$658K