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Denali Therapeutics
DNLI

190 hedge funds and large institutions have $2.8B invested in Denali Therapeutics in 2022 Q1 according to their latest regulatory filings, with 19 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 40 closing their positions.

New
Increased
Maintained
Reduced
Closed

0.82% more ownership

Funds ownership: 69.82% → 70.64% (+0.82%)

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

11% less funds holding

Funds holding: 213 → 190 (-23)

26% less capital invested

Capital invested by funds: $3.8B → $2.8B (-$998M)

53% less first-time investments, than exits

New positions opened: 19 | Existing positions closed: 40

55% less call options, than puts

Call options by funds: $818K | Put options by funds: $1.8M

Holders
190
Holders Change
-23
Holders Change %
-10.8%
% of All Funds
3%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
19
Increased
68
Reduced
69
Closed
40
Calls
$818K
Puts
$1.8M
Net Calls
-$986K
Net Calls Change
+$7.7M

Top Buyers

Rank Fund Capital Flow
1
State Street
State Street
Massachusetts
+$27.5M
2
YCM
Yiheng Capital Management
California
+$23.4M
3
Bank of New York Mellon
Bank of New York Mellon
New York
+$23.3M
4
Morgan Stanley
Morgan Stanley
New York
+$14.4M
5
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$9.91M

Top Sellers

Rank Fund Capital Flow
1
BAMCO Inc
BAMCO Inc
New York
-$11.7M
2
Jennison Associates
Jennison Associates
New York
-$10M
3
GGHC
Gilder Gagnon Howe & Co
New York
-$9.67M
4
CM
Crestline Management
Texas
-$8.41M
5
Marshall Wace
Marshall Wace
United Kingdom
-$7.95M
Name Holding Trade Value Shares
Change 		Change in
Stake
Russell Investments Group
76
Russell Investments Group
United Kingdom
$1.66M -$502K -14,601 -22%
PIM
77
Platinum Investment Management
Australia
$1.64M – – –
MIM
78
MetLife Investment Management
New Jersey
$1.62M +$619K +18,003 +56%
AIG
79
American International Group
New York
$1.45M -$109K -3,179 -7%
Los Angeles Capital Management
80
Los Angeles Capital Management
California
$1.36M +$39.9K +1,160 +3%
AG
81
AIA Group
Hong Kong
$1.33M -$2.29M -66,457 -62%
Allspring Global Investments
82
Allspring Global Investments
North Carolina
$1.29M +$55.2K +1,605 +4%
UBS Group
83
UBS Group
Switzerland
$1.26M -$1.83M -53,236 -58%
Voloridge Investment Management
84
Voloridge Investment Management
Florida
$1.2M +$807K +23,448 +168%
CGL
85
Clarius Group LLC
Washington
$1.18M – – –
Citigroup
86
Citigroup
New York
$1.14M -$2.92M -84,997 -71%
Squarepoint
87
Squarepoint
New York
$1.11M +$1.18M +34,435 New
DA
88
Duality Advisers
Florida
$1.1M +$1.18M +34,200 New
Envestnet Asset Management
89
Envestnet Asset Management
Illinois
$1.07M +$165K +4,795 +17%
ProShare Advisors
90
ProShare Advisors
Maryland
$1.03M -$259K -7,521 -19%
SO
91
STRS Ohio
Ohio
$994K – – –
State Board of Administration of Florida Retirement System
92
State Board of Administration of Florida Retirement System
Florida
$980K – – –
Two Sigma Investments
93
Two Sigma Investments
New York
$965K +$737K +21,425 +250%
Walleye Capital
94
Walleye Capital
New York
$910K +$974K +28,296 New
CWM
95
Concentric Wealth Management
California
$900K – – –
PPA
96
Parametric Portfolio Associates
Washington
$887K -$168K -4,887 -15%
ACM
97
AlphaCrest Capital Management
New York
$875K +$598K +17,389 +177%
EAM
98
Erste Asset Management
Austria
$872K -$127K -3,700 -12%
IHAM
99
Integral Health Asset Management
New York
$836K -$2.55M -74,000 -74%
EVM
100
Eaton Vance Management
Massachusetts
$742K +$793K +23,057 New
2 3
4
5 6

DNLI Hedge Fund Activity: Q1 2022 in Review

190 of the 6,340 institutional investors tracked by Wall St. Rank reported a position in Denali Therapeutics (DNLI) for Q1 2022, worth a combined $2.8B — down 26% from $3.8B a quarter earlier.

Sellers outnumbered buyers: 40 funds closed out of DNLI and 19 opened new positions — a net loss of 21 holders — while 69 trimmed existing stakes and 68 added.

The largest buyer was State Street, adding an estimated $27.5M. The largest seller was BAMCO Inc, cutting an estimated $11.7M.

  • 190 institutional investors held Denali Therapeutics (DNLI) as of Q1 2022, down from 213 in Q4 2021.
  • Funds reported $2.8B of Denali Therapeutics stock for Q1 2022, down 26% quarter-over-quarter.
  • 19 funds opened new Denali Therapeutics positions in Q1 2022 and 40 closed out, a net change of -21 holders.
  • The largest Denali Therapeutics buyer in Q1 2022 was State Street, an estimated $27.5M added.
  • The largest Denali Therapeutics seller in Q1 2022 was BAMCO Inc, an estimated $11.7M sold.

Based on aggregated 13F filings for Q1 2022.