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Denali Therapeutics
DNLI

Overview Fund Activity

230 hedge funds and large institutions have $1.93B invested in Denali Therapeutics in 2025 Q2 according to their latest regulatory filings, with 46 funds opening new positions, 83 increasing their positions, 64 reducing their positions, and 36 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
230
Holders Change
+9
Holders Change %
+4.07%
% of All Funds
3.08%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
46
Increased
83
Reduced
64
Closed
36
Calls
$2.08M
Puts
$630K
Net Calls
+$1.45M
Net Calls Change
+$1.12M

Top Buyers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$45.4M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
+$31M
3
Point72 Asset Management
Point72 Asset Management
Connecticut
+$31M
4
MCM
Masters Capital Management
Georgia
+$8.39M
5
Voloridge Investment Management
Voloridge Investment Management
Florida
+$6.56M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$80.4M
2
BlackRock
BlackRock
New York
-$24.9M
3
CCM
Camber Capital Management
Massachusetts
-$11.9M
4
Marshall Wace
Marshall Wace
United Kingdom
-$11M
5
Squarepoint
Squarepoint
New York
-$9.34M
Name Holding Trade Value Shares
Change 		Shares
Change %
CGL
51
Clarius Group LLC
Washington
$5.16M – – –
EP
52
Edgestream Partners
New Jersey
$4.8M +$4.8M +342,923 New
American Century Companies
53
American Century Companies
Missouri
$4.45M -$437K -31,227 -9%
Manulife (Manufacturers Life Insurance)
54
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$4.41M +$797K +56,970 +22%
PC
55
Pier Capital
Connecticut
$4.4M -$290K -20,708 -6%
Axa
56
Axa
France
$4.11M +$6.6K +472 +0.2%
Hudson Bay Capital Management
57
Hudson Bay Capital Management
Connecticut
$4.06M +$560K +40,000 +16%
MG
58
Marex Group
$3.67M +$3.67M +262,000 New
Swiss National Bank
59
Swiss National Bank
Switzerland
$3.51M – – –
PAI
60
Palo Alto Investors
California
$3.35M +$3.35M +239,809 New
Invesco
61
Invesco
Georgia
$3.07M +$425K +30,368 +16%
RhumbLine Advisers
62
RhumbLine Advisers
Massachusetts
$2.97M +$311K +22,247 +12%
TC
63
TwinBeech Capital
New York
$2.94M +$1.94M +138,348 +192%
EDRH
64
Edmond de Rothschild Holding
Switzerland
$2.88M – – –
SCM
65
SCS Capital Management
Massachusetts
$2.77M – – –
Renaissance Technologies
66
Renaissance Technologies
New York
$2.74M +$316K +22,600 +13%
JPMorgan Chase & Co
67
JPMorgan Chase & Co
New York
$2.68M +$44.9K +3,210 +2%
SCM
68
Soleus Capital Management
Connecticut
$2.55M +$659K +47,110 +35%
GAM
69
Groupama Asset Management
France
$2.47M +$438K +31,043 +21%
TRSOTSOK
70
Teachers Retirement System of the State of Kentucky
Kentucky
$2.4M -$166K -11,839 -6%
DCM
71
DAFNA Capital Management
California
$2.36M +$568K +40,600 +32%
Susquehanna International Group
72
Susquehanna International Group
Pennsylvania
$2.25M -$84.8K -6,061 -4%
CCIA
73
Campbell & Co Investment Adviser
Maryland
$2M +$1.04M +74,523 +109%
State of New Jersey Common Pension Fund D
74
State of New Jersey Common Pension Fund D
New Jersey
$1.93M +$620K +44,290 +47%
Deutsche Bank
75
Deutsche Bank
Germany
$1.9M -$284K -20,283 -13%
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