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Denali Therapeutics

222 hedge funds and large institutions have $1.85B invested in Denali Therapeutics in 2025 Q1 according to their latest regulatory filings, with 35 funds opening new positions, 74 increasing their positions, 81 reducing their positions, and 34 closing their positions.

New
Increased
Maintained
Reduced
Closed

65% more call options, than puts

Call options by funds: $848K | Put options by funds: $515K

4.71% more ownership

Funds ownership: 88.89%93.6% (+4.7%)

3% more first-time investments, than exits

New positions opened: 35 | Existing positions closed: 34

0% less funds holding

Funds holding: 223222 (-1)

9% less repeat investments, than reductions

Existing positions increased: 74 | Existing positions reduced: 81

29% less capital invested

Capital invested by funds: $2.61B → $1.85B (-$758M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
222
Holders Change
-1
Holders Change %
-0.45%
% of All Funds
2.98%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
35
Increased
74
Reduced
81
Closed
34
Calls
$848K
Puts
$515K
Net Calls
+$333K
Net Calls Change
-$267K
Name Holding Trade Value Shares
Change
Change in
Stake
Manulife (Manufacturers Life Insurance)
51
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$3.51M +$951K +49,611 +24%
Swiss National Bank
52
Swiss National Bank
Switzerland
$3.41M -$49.8K -2,600 -1%
BCM
53
Boxer Capital Management
California
$3.4M +$4.79M +250,000 New
Hudson Bay Capital Management
54
Hudson Bay Capital Management
Connecticut
$3.4M +$3.02M +157,500 +170%
Barclays
55
Barclays
United Kingdom
$3.27M -$717K -37,419 -13%
Jane Street
56
Jane Street
New York
$2.9M -$297K -15,492 -7%
EDRH
57
Edmond de Rothschild Holding
Switzerland
$2.8M
SCM
58
SCS Capital Management
Massachusetts
$2.69M +$3.79M +197,998 New
Citigroup
59
Citigroup
New York
$2.64M +$523K +27,298 +16%
RhumbLine Advisers
60
RhumbLine Advisers
Massachusetts
$2.59M -$2.57K -134 -0.1%
Invesco
61
Invesco
Georgia
$2.58M +$1.3M +67,949 +56%
JP Morgan Chase
62
JP Morgan Chase
New York
$2.56M -$663K -34,580 -16%
TRSOTSOK
63
Teachers Retirement System of the State of Kentucky
Kentucky
$2.49M -$455K -23,732 -11%
Renaissance Technologies
64
Renaissance Technologies
New York
$2.35M +$3.32M +173,100 New
Man Group
65
Man Group
United Kingdom
$2.3M +$2.82M +146,950 +655%
Susquehanna International Group
66
Susquehanna International Group
Pennsylvania
$2.27M +$1.84M +95,957 +135%
GAM
67
Groupama Asset Management
France
$2.14M +$657K +34,281 +31%
Deutsche Bank
68
Deutsche Bank
Germany
$2.13M -$2.33M -121,601 -44%
Legal & General Group
69
Legal & General Group
United Kingdom
$2.07M +$46.9K +2,449 +2%
SCM
70
Soleus Capital Management
Connecticut
$1.84M +$2.59M +135,000 New
Rafferty Asset Management
71
Rafferty Asset Management
New York
$1.76M -$233K -12,175 -9%
DCM
72
DAFNA Capital Management
California
$1.74M +$2.45M +127,900 New
California State Teachers Retirement System (CalSTRS)
73
California State Teachers Retirement System (CalSTRS)
California
$1.6M -$50.6K -2,639 -2%
WP
74
Woodline Partners
California
$1.54M +$259K +13,517 +14%
TI
75
Trexquant Investment
Connecticut
$1.54M +$1.01M +52,568 +87%