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DFTX

Definium Therapeutics

190 hedge funds and large institutions have $241M invested in Definium Therapeutics in 2025 Q1 according to their latest regulatory filings, with 39 funds opening new positions, 49 increasing their positions, 47 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

105% more call options, than puts

Call options by funds: $7.79M | Put options by funds: $3.8M

86% more first-time investments, than exits

New positions opened: 39 | Existing positions closed: 21

10% more funds holding

Funds holding: 172190 (+18)

4% more repeat investments, than reductions

Existing positions increased: 49 | Existing positions reduced: 47

0% more funds holding in top 10

Funds holding in top 10: 33 (0)

1.99% less ownership

Funds ownership: 56.6%54.61% (-2%)

17% less capital invested

Capital invested by funds: $289M → $241M (-$48.3M)

Holders
190
Holders Change
+18
Holders Change %
+10.47%
% of All Funds
2.55%
Holding in Top 10
3
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.04%
New
39
Increased
49
Reduced
47
Closed
21
Calls
$7.79M
Puts
$3.8M
Net Calls
+$3.99M
Net Calls Change
-$5.6M
Name Holding Trade Value Shares
Change
Change in
Stake
Barclays
26
Barclays
United Kingdom
$700K -$257K -35,861 -23%
AI
27
AdvisorShares Investments
Maryland
$663K +$114K +15,884 +15%
RhumbLine Advisers
28
RhumbLine Advisers
Massachusetts
$634K +$55.6K +7,762 +8%
UBS Group
29
UBS Group
Switzerland
$632K -$45.9K -6,412 -6%
Swiss National Bank
30
Swiss National Bank
Switzerland
$624K -$95.3K -13,300 -11%
DCI
31
Data Collective IV
California
$587K
Bank of America
32
Bank of America
North Carolina
$516K -$1.32M -184,707 -68%
AllianceBernstein
33
AllianceBernstein
Tennessee
$442K +$54.8K +7,650 +11%
Jane Street
34
Jane Street
New York
$433K +$411K +57,432 +347%
Citigroup
35
Citigroup
New York
$416K -$41.1K -5,733 -7%
OC
36
Oppenheimer & Co
New York
$416K +$39.9K +5,574 +9%
LPL Financial
37
LPL Financial
California
$394K +$36.5K +5,099 +8%
Royal Bank of Canada
38
Royal Bank of Canada
Ontario, Canada
$382K +$44K +6,148 +10%
Creative Planning
39
Creative Planning
Kansas
$377K +$462K +64,442 New
D.E. Shaw & Co
40
D.E. Shaw & Co
New York
$370K +$453K +63,249 New
IC
41
Ikarian Capital
Texas
$367K
Deutsche Bank
42
Deutsche Bank
Germany
$346K -$88.6K -12,369 -17%
Two Sigma Investments
43
Two Sigma Investments
New York
$346K -$867K -121,071 -67%
California State Teachers Retirement System (CalSTRS)
44
California State Teachers Retirement System (CalSTRS)
California
$342K
Legal & General Group
45
Legal & General Group
United Kingdom
$335K -$8.19K -1,144 -2%
IIM
46
INTECH Investment Management
Florida
$322K +$182K +25,428 +86%
SC
47
Scotia Capital
Ontario, Canada
$315K +$143 +20 +0%
KPWS
48
Kestra Private Wealth Services
Texas
$294K -$7.16K -1,000 -2%
DS
49
DRW Securities
Illinois
$293K +$358K +50,000 New
MIM
50
MetLife Investment Management
New Jersey
$288K -$3.34K -466 -0.9%

DFTX Hedge Fund Activity: Q1 2025 in Review

190 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Definium Therapeutics (DFTX) for Q1 2025, worth a combined $241M — down 17% from $289M a quarter earlier.

Buyers outnumbered sellers: 39 funds opened new DFTX positions and 21 closed out — a net gain of 18 holders — while 49 added to existing stakes and 47 trimmed.

The largest buyer was Rosalind Advisors, opening a new position worth an estimated $3.01M. The largest seller was Tri Locum Partners, exiting entirely with an estimated $5.71M sold.

  • 190 institutional investors held Definium Therapeutics (DFTX) as of Q1 2025, up from 172 in Q4 2024.
  • Funds reported $241M of Definium Therapeutics stock for Q1 2025, down 17% quarter-over-quarter.
  • 39 funds opened new Definium Therapeutics positions in Q1 2025 and 21 closed out, a net change of +18 holders.
  • The largest Definium Therapeutics buyer in Q1 2025 was Rosalind Advisors, an estimated $3.01M added.
  • The largest Definium Therapeutics seller in Q1 2025 was Tri Locum Partners, an estimated $5.71M sold.

Based on aggregated 13F filings for Q1 2025.