Two Sigma Investments
DFTX

Two Sigma Investments’s Definium Therapeutics DFTX Stock Holding History

Two Sigma Investments’s Portfolio DFTX Stock Details DFTX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$22.7M Buy
1,201,610
+776,403
+183% +$13.2M 0.02% 881
2025
Q4 		$5.69M Buy
425,207
+128,764
+43% +$1.59M 0.01% 1592
2025
Q3 		$3.5M Buy
296,443
+239,965
+425% +$2.24M 0.01% 1742
2025
Q2 		$367K Sell
56,478
-2,744
-5% -$18K ﹤0.01% 2715
2025
Q1 		$346K Sell
59,222
-121,071
-67% -$867K ﹤0.01% 2658
2024
Q4 		$1.25M Sell
180,293
-98,746
-35% -$679K ﹤0.01% 2029
2024
Q3 		$1.59M Sell
279,039
-404,648
-59% -$2.81M ﹤0.01% 1811
2024
Q2 		$4.93M Sell
683,687
-28,551
-4% -$250K 0.01% 1018
2024
Q1 		$6.7M Buy
712,238
+573,142
+412% +$3.27M 0.02% 823
2023
Q4 		$509K Sell
139,096
-18,343
-12% -$55.2K ﹤0.01% 2450
2023
Q3 		$493K Sell
157,439
-305
-0.2% -$1.25K ﹤0.01% 2284
2023
Q2 		$563K Sell
157,744
-10,441
-6% -$36K ﹤0.01% 2282
2023
Q1 		$533K Buy
168,185
+134,313
+397% +$447K ﹤0.01% 2175
2022
Q4 		$74.5K Buy
+33,872
New +$94.1K ﹤0.01% 2544
2022
Q3 		– Sell
-24,855
Closed -$239K – 2681
2022
Q2 		$239K Sell
24,855
-20,330
-45% -$257K ﹤0.01% 2106
2022
Q1 		$752K Sell
45,185
-29,733
-40% -$516K ﹤0.01% 1826
2021
Q4 		$1.55M Buy
74,918
+52,724
+238% +$1.68M ﹤0.01% 2153
2021
Q3 		$776K Buy
+22,194
New +$960K ﹤0.01% 2853

Other funds holding DFTX

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
OCA
Octagon Capital Advisors New York $904M AUM 737.04% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Two Sigma Investments's DFTX Position: Q1 2026 in Review

Two Sigma Investments increased its Definium Therapeutics (DFTX) stake by 183% in Q1 2026, buying an estimated $13.2M and bringing the position to 1,201,610 shares worth $22.7M. The position accounts for 0.02% of the portfolio, ranked #881.

Two Sigma Investments first reported a position in DFTX in Q3 2021 and has held it in 18 quarters since. 247 funds tracked by Wall St. Rank hold DFTX as of Q1 2026.

  • Two Sigma Investments held 1,201,610 shares of Definium Therapeutics worth $22.7M as of Q1 2026.
  • Two Sigma Investments bought 776,403 Definium Therapeutics shares in Q1 2026, an estimated $13.2M.
  • Definium Therapeutics made up 0.02% of Two Sigma Investments's portfolio in Q1 2026, its #881 holding.
  • Two Sigma Investments first reported a position in Definium Therapeutics in Q3 2021 and has held it in 18 quarters since.
  • 247 funds tracked by Wall St. Rank held Definium Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.