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CRISPR Therapeutics

433 hedge funds and large institutions have $3.52B invested in CRISPR Therapeutics in 2025 Q2 according to their latest regulatory filings, with 101 funds opening new positions, 127 increasing their positions, 101 reducing their positions, and 60 closing their positions.

New
Increased
Maintained
Reduced
Closed

68% more first-time investments, than exits

New positions opened: 101 | Existing positions closed: 60

60% more capital invested

Capital invested by funds: $2.2B → $3.52B (+$1.32B)

31% more call options, than puts

Call options by funds: $244M | Put options by funds: $186M

26% more repeat investments, than reductions

Existing positions increased: 127 | Existing positions reduced: 101

9% more funds holding

Funds holding: 396433 (+37)

8.4% more ownership

Funds ownership: 75.39%83.79% (+8.4%)

0% more funds holding in top 10

Funds holding in top 10: 66 (0)

Holders
433
Holders Change
+37
Holders Change %
+9.34%
% of All Funds
5.7%
Holding in Top 10
6
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.08%
New
101
Increased
127
Reduced
101
Closed
60
Calls
$244M
Puts
$186M
Net Calls
+$58.2M
Net Calls Change
+$37.5M
Name Holding Trade Value Shares
Change
Change in
Stake
AIM
1
ARK Investment Management
Florida
$495M +$665K +17,190 +0.2%
BlackRock
2
BlackRock
New York
$295M +$134M +3,452,819 +132%
Capital International Investors
3
Capital International Investors
California
$272M -$18.6M -479,371 -8%
T. Rowe Price Investment Management
4
T. Rowe Price Investment Management
Maryland
$179M -$4.45M -115,077 -3%
State Street
5
State Street
Massachusetts
$159M +$33.3M +859,334 +36%
UBS Group
6
UBS Group
Switzerland
$138M +$29.9M +771,685 +37%
OAG
7
Orbis Allan Gray
Bermuda
$134M +$46.5M +1,201,600 +77%
Sumitomo Mitsui Trust Group
8
Sumitomo Mitsui Trust Group
Japan
$117M -$4.84M -125,051 -5%
NAMA
9
Nikko Asset Management Americas
New York
$117M -$4.86M -125,618 -5%
Vanguard Group
10
Vanguard Group
Pennsylvania
$112M +$20.4M +528,380 +30%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$101M +$39.7M +1,025,979 +98%
Fidelity Investments
12
Fidelity Investments
Massachusetts
$93.8M -$441K -11,391 -0.6%
NMC
13
NEA Management Company
Maryland
$77.2M
Two Sigma Investments
14
Two Sigma Investments
New York
$75.2M +$13.8M +356,807 +30%
Bank of America
15
Bank of America
North Carolina
$70.5M +$2.39M +61,645 +4%
EC
16
EcoR1 Capital
California
$67.6M
Two Sigma Advisers
17
Two Sigma Advisers
New York
$65.4M +$21.2M +547,500 +69%
SOCM
18
SR One Capital Management
Pennsylvania
$51M
UBS AM
19
UBS AM
Illinois
$46.9M -$38.2M -988,061 -51%
Charles Schwab
20
Charles Schwab
California
$45.4M +$8.5M +219,665 +31%
Dimensional Fund Advisors
21
Dimensional Fund Advisors
Texas
$44.6M -$752K -19,433 -2%
Loomis, Sayles & Company
22
Loomis, Sayles & Company
Massachusetts
$41.7M -$2.05M -52,905 -6%
Susquehanna International Group
23
Susquehanna International Group
Pennsylvania
$37.5M +$18.5M +478,929 +165%
Northern Trust
24
Northern Trust
Illinois
$37M +$20.3M +523,467 +220%
National Bank of Canada
25
National Bank of Canada
Quebec, Canada
$35.8M +$28.5M +735,600 New

CRSP Hedge Fund Activity: Q2 2025 in Review

433 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in CRISPR Therapeutics (CRSP) for Q2 2025, worth a combined $3.52B — up 60% from $2.2B a quarter earlier.

Buyers outnumbered sellers: 101 funds opened new CRSP positions and 60 closed out — a net gain of 41 holders — while 127 added to existing stakes and 101 trimmed.

The largest buyer was BlackRock, adding an estimated $134M. The largest seller was UBS AM, cutting an estimated $38.2M.

  • 433 institutional investors held CRISPR Therapeutics (CRSP) as of Q2 2025, up from 396 in Q1 2025.
  • Funds reported $3.52B of CRISPR Therapeutics stock for Q2 2025, up 60% quarter-over-quarter.
  • 101 funds opened new CRISPR Therapeutics positions in Q2 2025 and 60 closed out, a net change of +41 holders.
  • The largest CRISPR Therapeutics buyer in Q2 2025 was BlackRock, an estimated $134M added.
  • The largest CRISPR Therapeutics seller in Q2 2025 was UBS AM, an estimated $38.2M sold.

Based on aggregated 13F filings for Q2 2025.