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CRISPR Therapeutics

396 hedge funds and large institutions have $2.2B invested in CRISPR Therapeutics in 2025 Q1 according to their latest regulatory filings, with 55 funds opening new positions, 123 increasing their positions, 102 reducing their positions, and 59 closing their positions.

New
Increased
Maintained
Reduced
Closed

50% more funds holding in top 10

Funds holding in top 10: 46 (+2)

27% more call options, than puts

Call options by funds: $96.3M | Put options by funds: $75.6M

21% more repeat investments, than reductions

Existing positions increased: 123 | Existing positions reduced: 102

0.25% less ownership

Funds ownership: 75.64%75.39% (-0.25%)

7% less first-time investments, than exits

New positions opened: 55 | Existing positions closed: 59

2% less funds holding

Funds holding: 404396 (-8)

13% less capital invested

Capital invested by funds: $2.54B → $2.2B (-$339M)

Holders
396
Holders Change
-8
Holders Change %
-1.98%
% of All Funds
5.31%
Holding in Top 10
6
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+50%
% of All Funds
0.08%
New
55
Increased
123
Reduced
102
Closed
59
Calls
$96.3M
Puts
$75.6M
Net Calls
+$20.7M
Net Calls Change
+$30.7M
Name Holding Trade Value Shares
Change
Change in
Stake
AIM
1
ARK Investment Management
Florida
$346M +$50.5M +1,192,336 +13%
Capital International Investors
2
Capital International Investors
California
$207M -$113M -2,670,405 -31%
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$129M -$577K -13,605 -0.4%
BlackRock
4
BlackRock
New York
$88.9M -$6.18M -145,787 -5%
Sumitomo Mitsui Trust Group
5
Sumitomo Mitsui Trust Group
Japan
$86.4M -$8.72M -205,787 -7%
NAMA
6
Nikko Asset Management Americas
New York
$86.3M -$8.72M -205,787 -7%
State Street
7
State Street
Massachusetts
$82.1M -$3.4M -80,263 -3%
UBS Group
8
UBS Group
Switzerland
$70.5M +$3.73M +87,902 +4%
UBS AM
9
UBS AM
Illinois
$66.5M +$53.5M +1,262,560 +183%
Fidelity Investments
10
Fidelity Investments
Massachusetts
$66M -$12M -282,748 -13%
Vanguard Group
11
Vanguard Group
Pennsylvania
$60.2M +$1.43M +33,711 +2%
NMC
12
NEA Management Company
Maryland
$54M
OAG
13
Orbis Allan Gray
Bermuda
$53.2M +$3.68M +86,813 +6%
EC
14
EcoR1 Capital
California
$47.3M
Bank of America
15
Bank of America
North Carolina
$47.2M +$7.43M +175,261 +14%
Morgan Stanley
16
Morgan Stanley
New York
$44.2M +$34.1M +804,980 +163%
Two Sigma Investments
17
Two Sigma Investments
New York
$40.5M +$37.4M +882,887 +288%
SOCM
18
SR One Capital Management
Pennsylvania
$35.7M
Geode Capital Management
19
Geode Capital Management
Massachusetts
$35.6M +$1.91M +45,036 +4%
Dimensional Fund Advisors
20
Dimensional Fund Advisors
Texas
$31.9M -$431K -10,156 -1%
Loomis, Sayles & Company
21
Loomis, Sayles & Company
Massachusetts
$31M -$49.7K -1,173 -0.1%
Two Sigma Advisers
22
Two Sigma Advisers
New York
$27.1M +$30.2M +712,400 +840%
Charles Schwab
23
Charles Schwab
California
$24.3M -$402K -9,493 -1%
BBA
24
Baker Bros. Advisors
New York
$22.3M -$27.7M -653,912 -50%
Millennium Management
25
Millennium Management
New York
$19.9M +$24.4M +575,235 +6,769%

CRSP Hedge Fund Activity: Q1 2025 in Review

396 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in CRISPR Therapeutics (CRSP) for Q1 2025, worth a combined $2.2B — down 13% from $2.54B a quarter earlier.

Sellers outnumbered buyers: 59 funds closed out of CRSP and 55 opened new positions — a net loss of 4 holders — while 102 trimmed existing stakes and 123 added.

The largest buyer was UBS AM, adding an estimated $53.5M. The largest seller was Capital International Investors, cutting an estimated $113M.

  • 396 institutional investors held CRISPR Therapeutics (CRSP) as of Q1 2025, down from 404 in Q4 2024.
  • Funds reported $2.2B of CRISPR Therapeutics stock for Q1 2025, down 13% quarter-over-quarter.
  • 55 funds opened new CRISPR Therapeutics positions in Q1 2025 and 59 closed out, a net change of -4 holders.
  • The largest CRISPR Therapeutics buyer in Q1 2025 was UBS AM, an estimated $53.5M added.
  • The largest CRISPR Therapeutics seller in Q1 2025 was Capital International Investors, an estimated $113M sold.

Based on aggregated 13F filings for Q1 2025.