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Axsome Therapeutics
AXSM

352 hedge funds and large institutions have $4.37B invested in Axsome Therapeutics in 2025 Q1 according to their latest regulatory filings, with 90 funds opening new positions, 104 increasing their positions, 115 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

221% more first-time investments, than exits

New positions opened: 90 | Existing positions closed: 28

39% more capital invested

Capital invested by funds: $3.15B → $4.37B (+$1.22B)

28% more call options, than puts

Call options by funds: $111M | Put options by funds: $86.5M

21% more funds holding

Funds holding: 292 → 352 (+60)

9% more funds holding in top 10

Funds holding in top 10: 11 → 12 (+1)

0.05% more ownership

Funds ownership: 76.73% → 76.78% (+0.05%)

10% less repeat investments, than reductions

Existing positions increased: 104 | Existing positions reduced: 115

Holders
352
Holders Change
+60
Holders Change %
+20.55%
% of All Funds
4.72%
Holding in Top 10
12
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+9.09%
% of All Funds
0.16%
New
90
Increased
104
Reduced
115
Closed
28
Calls
$111M
Puts
$86.5M
Net Calls
+$24.5M
Net Calls Change
-$35M

Top Buyers

1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$71.1M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$60.1M
3
O
OrbiMed
New York
+$44.1M
4
1832 Asset Management
1832 Asset Management
Ontario, Canada
+$41.4M
5
Man Group
Man Group
United Kingdom
+$39.9M

Top Sellers

1
RI
RTW Investments
New York
-$129M
2
RCM
RA Capital Management
Massachusetts
-$84.6M
3
FFM
Fairmount Funds Management
Pennsylvania
-$74.5M
4
Lazard Asset Management
Lazard Asset Management
New York
-$57.9M
5
HRCM
Hood River Capital Management
Florida
-$54.6M
Name Holding Trade Value Shares
Change 		Change in
Stake
Two Sigma Investments
101
Two Sigma Investments
New York
$5.48M +$5.36M +47,005 New
Canada Pension Plan Investment Board
102
Canada Pension Plan Investment Board
Ontario, Canada
$5.19M +$4.6M +40,400 +985%
NIP
103
Nicholas Investment Partners
California
$5.08M +$3.81M +33,437 +330%
FCM
104
Frontier Capital Management
Massachusetts
$5.05M -$1.08M -9,507 -18%
BA
105
Bridgewater Associates
Connecticut
$4.99M +$4.88M +42,825 New
EI
106
EAM Investors
California
$4.92M +$4.81M +42,222 New
EGI
107
EAM Global Investors
California
$4.89M +$4.78M +41,922 New
Wells Fargo
108
Wells Fargo
California
$4.85M +$214K +1,879 +5%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
109
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$4.81M +$4.69M +41,200 New
Tudor Investment Corp
110
Tudor Investment Corp
Connecticut
$4.77M +$4.66M +40,866 New
MOACM
111
Mutual of America Capital Management
New York
$4.62M +$15.5K +136 +0.3%
Citigroup
112
Citigroup
New York
$4.57M -$432K -3,792 -9%
Legal & General Group
113
Legal & General Group
United Kingdom
$4.21M -$29.7K -261 -0.7%
SEI Investments
114
SEI Investments
Pennsylvania
$4.17M -$1.42M -12,501 -26%
PCA
115
Pallas Capital Advisors
Massachusetts
$4.11M +$1.01M +8,845 +33%
SCM
116
SVB Capital Management
California
$3.95M – – –
TAM
117
TFG Asset Management
Cayman Islands
$3.94M -$848K -7,444 -18%
New York State Common Retirement Fund
118
New York State Common Retirement Fund
New York
$3.92M +$1.26M +11,090 +49%
LCG
119
Lisanti Capital Growth
New York
$3.88M +$3.79M +33,280 New
AA
120
ALPS Advisors
Colorado
$3.77M -$778K -6,826 -17%
T. Rowe Price Associates
121
T. Rowe Price Associates
Maryland
$3.73M +$85.3K +749 +2%
State of Wisconsin Investment Board
122
State of Wisconsin Investment Board
Wisconsin
$3.59M +$387K +3,401 +12%
RA
123
Royce & Associates
New York
$3.53M -$768K -6,743 -18%
DekaBank Deutsche Girozentrale
124
DekaBank Deutsche Girozentrale
Germany
$3.52M – – –
TF
125
Trek Financial
Arizona
$3.45M +$3.37M +29,544 New
3 4
5
6 7

AXSM Hedge Fund Activity: Q1 2025 in Review

352 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Axsome Therapeutics (AXSM) for Q1 2025, worth a combined $4.37B — up 39% from $3.15B a quarter earlier.

Buyers outnumbered sellers: 90 funds opened new AXSM positions and 28 closed out — a net gain of 62 holders — while 104 added to existing stakes and 115 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $71.1M. The largest seller was RTW Investments, cutting an estimated $129M.

  • 352 institutional investors held Axsome Therapeutics (AXSM) as of Q1 2025, up from 292 in Q4 2024.
  • Funds reported $4.37B of Axsome Therapeutics stock for Q1 2025, up 39% quarter-over-quarter.
  • 90 funds opened new Axsome Therapeutics positions in Q1 2025 and 28 closed out, a net change of +62 holders.
  • The largest Axsome Therapeutics buyer in Q1 2025 was Assenagon Asset Management, an estimated $71.1M added.
  • The largest Axsome Therapeutics seller in Q1 2025 was RTW Investments, an estimated $129M sold.

Based on aggregated 13F filings for Q1 2025.