Two Sigma Investments
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Two Sigma Investments’s Axsome Therapeutics AXSM Stock Holding History

Two Sigma Investments’s Portfolio AXSM Stock Details AXSM Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$54.6M Buy
322,778
+177,181
+122% +$30.6M 0.04% 467
2025
Q4 		$26.6M Buy
145,597
+137,390
+1,674% +$19.2M 0.04% 587
2025
Q3 		$997K Buy
+8,207
New +$924K ﹤0.01% 2574
2025
Q2 		– Sell
-47,005
Closed -$5.48M – 3186
2025
Q1 		$5.48M Buy
+47,005
New +$5.36M 0.01% 1079
2022
Q4 		– Sell
-141,312
Closed -$6.3M – 2801
2022
Q3 		$6.3M Buy
+141,312
New +$7.06M 0.02% 664
2022
Q2 		– Sell
-52,874
Closed -$2.19M – 2507
2022
Q1 		$2.19M Sell
52,874
-39,696
-43% -$1.23M 0.01% 1309
2021
Q4 		$3.5M Buy
92,570
+71,370
+337% +$2.63M 0.01% 1449
2021
Q3 		$699K Buy
+21,200
New +$826K ﹤0.01% 2955
2021
Q2 		– Sell
-161,801
Closed -$9.16M – 4038
2021
Q1 		$9.16M Buy
161,801
+145,901
+918% +$10.3M 0.02% 737
2020
Q4 		$1.29M Buy
+15,900
New +$1.19M ﹤0.01% 1801

Other funds holding AXSM

BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
VPM
Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
Invesco
Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's AXSM Position: Q1 2026 in Review

Two Sigma Investments increased its Axsome Therapeutics (AXSM) stake by 122% in Q1 2026, buying an estimated $30.6M and bringing the position to 322,778 shares worth $54.6M. The position accounts for 0.04% of the portfolio, ranked #467.

Two Sigma Investments first reported a position in AXSM in Q4 2020 and has held it in 10 quarters since. 409 funds tracked by Wall St. Rank hold AXSM as of Q1 2026.

  • Two Sigma Investments held 322,778 shares of Axsome Therapeutics worth $54.6M as of Q1 2026.
  • Two Sigma Investments bought 177,181 Axsome Therapeutics shares in Q1 2026, an estimated $30.6M.
  • Axsome Therapeutics made up 0.04% of Two Sigma Investments's portfolio in Q1 2026, its #467 holding.
  • Two Sigma Investments first reported a position in Axsome Therapeutics in Q4 2020 and has held it in 10 quarters since.
  • 409 funds tracked by Wall St. Rank held Axsome Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.