Applied Therapeutics
APLT
APLT was delisted on the 2nd of February, 2026.
52 hedge funds and large institutions have $5.93M invested in Applied Therapeutics in 2025 Q4 according to their latest regulatory filings, with 9 funds opening new positions, 13 increasing their positions, 19 reducing their positions, and 25 closing their positions.
18% less call options, than puts
Call options by funds: $33K | Put options by funds: $40K
25% less ownership
Funds ownership: 65.8% → 40.81% (-25%)
26% less funds holding
Funds holding: 70 → 52 (-18)
32% less repeat investments, than reductions
Existing positions increased: 13 | Existing positions reduced: 19
64% less first-time investments, than exits
New positions opened: 9 | Existing positions closed: 25
90% less capital invested
Capital invested by funds: $57.2M → $5.93M (-$51.3M)
100% less funds holding in top 10
Funds holding in top 10: 1 → 0 (-1)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DAM
Deltec Asset Management
New York
|
+$2.44M |
| 2 |
Renaissance Technologies
New York
|
+$1.72M |
| 3 |
Jane Street
New York
|
+$1.33M |
| 4 |
Vanguard Group
Malvern,
Pennsylvania
|
+$794K |
| 5 |
GCM
Graham Capital Management
Rowayton,
Connecticut
|
+$364K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
VPC
Vestal Point Capital
New York
|
-$8.62M |
| 2 |
PBM
Propel Bio Management
Los Angeles,
California
|
-$6.83M |
| 3 |
SAM
Simplify Asset Management
Las Vegas,
Nevada
|
-$2.71M |
| 4 |
PNC Financial Services Group
Pittsburgh,
Pennsylvania
|
-$1.76M |
| 5 |
Marshall Wace
London,
United Kingdom
|
-$1.4M |
APLT Hedge Fund Activity: Q4 2025 in Review
52 of the 8,235 institutional investors tracked by Wall St. Rank reported a position in Applied Therapeutics (APLT) for Q4 2025, worth a combined $5.93M — down 90% from $57.2M a quarter earlier.
Sellers outnumbered buyers: 25 funds closed out of APLT and 9 opened new positions — a net loss of 16 holders — while 19 trimmed existing stakes and 13 added.
The largest buyer was Deltec Asset Management, opening a new position worth an estimated $2.44M. The largest seller was Vestal Point Capital, exiting entirely with an estimated $8.62M sold.
- 52 institutional investors held Applied Therapeutics (APLT) as of Q4 2025, down from 70 in Q3 2025.
- Funds reported $5.93M of Applied Therapeutics stock for Q4 2025, down 90% quarter-over-quarter.
- 9 funds opened new Applied Therapeutics positions in Q4 2025 and 25 closed out, a net change of -16 holders.
- The largest Applied Therapeutics buyer in Q4 2025 was Deltec Asset Management, an estimated $2.44M added.
- The largest Applied Therapeutics seller in Q4 2025 was Vestal Point Capital, an estimated $8.62M sold.
Based on aggregated 13F filings for Q4 2025.