Two Sigma Investments
APLT

Two Sigma Investments’s Applied Therapeutics APLT Stock Holding History

Two Sigma Investments’s Portfolio APLT Stock Details APLT Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-198,933
Closed -$120K – 4062
2025
Q3 		$120K Sell
198,933
-395,601
-67% -$186K ﹤0.01% 3443
2025
Q2 		$185K Sell
594,534
-366,053
-38% -$142K ﹤0.01% 2927
2025
Q1 		$470K Buy
960,587
+666,777
+227% +$393K ﹤0.01% 2543
2024
Q4 		$252K Buy
+293,810
New +$1.84M ﹤0.01% 2801
2024
Q3 		– Sell
-43,338
Closed -$202K – 3103
2024
Q2 		$202K Sell
43,338
-111,820
-72% -$529K ﹤0.01% 2729
2024
Q1 		$1.06M Sell
155,158
-130,839
-46% -$587K ﹤0.01% 1929
2023
Q4 		$958K Buy
285,997
+216,646
+312% +$539K ﹤0.01% 2108
2023
Q3 		$173K Buy
69,351
+44,797
+182% +$73.8K ﹤0.01% 2666
2023
Q2 		$31.4K Sell
24,554
-64,595
-72% -$85.7K ﹤0.01% 2875
2023
Q1 		$72.3K Sell
89,149
-88,624
-50% -$87.3K ﹤0.01% 2710
2022
Q4 		$135K Sell
177,773
-3,828
-2% -$3.03K ﹤0.01% 2465
2022
Q3 		$169K Buy
181,601
+3,350
+2% +$4.02K ﹤0.01% 2144
2022
Q2 		$169K Sell
178,251
-102,022
-36% -$167K ﹤0.01% 2193
2022
Q1 		$591K Buy
280,273
+251,842
+886% +$675K ﹤0.01% 1941
2021
Q4 		$254K Sell
28,431
-703
-2% -$9.23K ﹤0.01% 3760
2021
Q3 		$484K Buy
29,134
+18,643
+178% +$322K ﹤0.01% 3294
2021
Q2 		$218K Buy
+10,491
New +$199K ﹤0.01% 3729
2020
Q4 		– Sell
-27,363
Closed -$568K – 3311
2020
Q3 		$568K Buy
+27,363
New +$711K ﹤0.01% 2149
2020
Q2 		– Sell
-7,834
Closed -$256K – 2914
2020
Q1 		$256K Buy
+7,834
New +$317K ﹤0.01% 2446

Other funds holding APLT

T. Rowe Price Investment Management
T. Rowe Price Investment Management Baltimore, Maryland $145B AUM 22.78% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
KCM
Knoll Capital Management Miami, Florida $180M AUM 66.11% 1-Year Est. Return
DAM
Deltec Asset Management New York $677M AUM 31.67% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Pathstone Holdings
Pathstone Holdings Englewood, New Jersey $25.1B AUM 22.95% 1-Year Est. Return
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
Jane Street
Jane Street New York $777B AUM 61.18% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return

Two Sigma Investments's APLT Position: Q4 2025 in Review

Two Sigma Investments sold out of Applied Therapeutics (APLT) in Q4 2025, closing a stake of 198,933 shares — an estimated $120K sold.

Two Sigma Investments first reported a position in APLT in Q1 2020 and held it in 19 quarters. The position peaked at $1.06M in Q1 2024. 52 funds tracked by Wall St. Rank hold APLT as of Q4 2025.

  • Two Sigma Investments reported no remaining Applied Therapeutics position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Investments sold 198,933 Applied Therapeutics shares in Q4 2025, an estimated $120K.
  • Two Sigma Investments first reported a position in Applied Therapeutics in Q1 2020 and held it in 19 quarters.
  • Two Sigma Investments's Applied Therapeutics position peaked at $1.06M in Q1 2024.
  • 52 funds tracked by Wall St. Rank held Applied Therapeutics as of Q4 2025.

Based on Two Sigma Investments's 13F filing for Q4 2025, filed 17 Feb 2026.