Applied Therapeutics
APLT
APLT was delisted on the 2nd of February, 2026.
90 hedge funds and large institutions have $51.8M invested in Applied Therapeutics in 2025 Q1 according to their latest regulatory filings, with 11 funds opening new positions, 27 increasing their positions, 32 reducing their positions, and 40 closing their positions.
133% more call options, than puts
Call options by funds: $226K | Put options by funds: $97K
7.75% less ownership
Funds ownership: 98.89% → 91.14% (-7.8%)
16% less repeat investments, than reductions
Existing positions increased: 27 | Existing positions reduced: 32
24% less funds holding
Funds holding: 119 → 90 (-29)
47% less capital invested
Capital invested by funds: $98.5M → $51.8M (-$46.7M)
50% less funds holding in top 10
Funds holding in top 10: 2 → 1 (-1)
73% less first-time investments, than exits
New positions opened: 11 | Existing positions closed: 40
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
T. Rowe Price Investment Management
Baltimore,
Maryland
|
+$2.92M |
| 2 |
KCM
Knoll Capital Management
Miami,
Florida
|
+$1.18M |
| 3 |
PBM
Propel Bio Management
Los Angeles,
California
|
+$983K |
| 4 |
SAM
Simplify Asset Management
Las Vegas,
Nevada
|
+$983K |
| 5 |
Two Sigma Investments
New York
|
+$393K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Morgan Stanley
New York
|
-$3.5M |
| 2 |
VA
VR Adviser
New York
|
-$2.6M |
| 3 |
SSA
Schonfeld Strategic Advisors
New York
|
-$2.41M |
| 4 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$1.4M |
| 5 |
Millennium Management
New York
|
-$718K |
APLT Hedge Fund Activity: Q1 2025 in Review
90 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Applied Therapeutics (APLT) for Q1 2025, worth a combined $51.8M — down 47% from $98.5M a quarter earlier.
Sellers outnumbered buyers: 40 funds closed out of APLT and 11 opened new positions — a net loss of 29 holders — while 32 trimmed existing stakes and 27 added.
The largest buyer was T. Rowe Price Investment Management, adding an estimated $2.92M. The largest seller was Morgan Stanley, cutting an estimated $3.5M.
- 90 institutional investors held Applied Therapeutics (APLT) as of Q1 2025, down from 119 in Q4 2024.
- Funds reported $51.8M of Applied Therapeutics stock for Q1 2025, down 47% quarter-over-quarter.
- 11 funds opened new Applied Therapeutics positions in Q1 2025 and 40 closed out, a net change of -29 holders.
- The largest Applied Therapeutics buyer in Q1 2025 was T. Rowe Price Investment Management, an estimated $2.92M added.
- The largest Applied Therapeutics seller in Q1 2025 was Morgan Stanley, an estimated $3.5M sold.
Based on aggregated 13F filings for Q1 2025.