Annexon
ANNX
144 hedge funds and large institutions have $309M invested in Annexon in 2025 Q3 according to their latest regulatory filings, with 33 funds opening new positions, 51 increasing their positions, 36 reducing their positions, and 17 closing their positions.
94% more first-time investments, than exits
New positions opened: 33 | Existing positions closed: 17
42% more repeat investments, than reductions
Existing positions increased: 51 | Existing positions reduced: 36
30% more capital invested
Capital invested by funds: $239M → $309M (+$70.5M)
12% more funds holding
Funds holding: 129 → 144 (+15)
1.38% more ownership
Funds ownership: 90.88% → 92.26% (+1.4%)
7% less call options, than puts
Call options by funds: $377K | Put options by funds: $405K
100% less funds holding in top 10
Funds holding in top 10: 1 → 0 (-1)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
OM
Opaleye Management
Boston,
Massachusetts
|
+$6.46M |
| 2 |
Morgan Stanley
New York
|
+$5.46M |
| 3 |
WP
Woodline Partners
San Francisco,
California
|
+$3.93M |
| 4 |
Adage Capital Partners
Boston,
Massachusetts
|
+$3.72M |
| 5 |
Balyasny Asset Management
Chicago,
Illinois
|
+$3.22M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
-$11.5M |
| 2 |
SCM
Sio Capital Management
New York
|
-$9.83M |
| 3 |
LGM
Logos Global Management
San Francisco,
California
|
-$5.78M |
| 4 |
Walleye Capital
New York
|
-$1.91M |
| 5 |
TAM
TFG Asset Management
Grand Cayman,
Cayman Islands
|
-$1.73M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
N
151
Natixis
Paris,
France
| – | -$185K | -77,100 | Closed |
|
|
VF
152
Virtu Financial
New York
| – | -$73K | -30,597 | Closed |
|
153
Marshall Wace
London,
United Kingdom
| – | -$72K | -29,989 | Closed |
|
|
QC
154
Quadrature Capital
London,
United Kingdom
| – | -$49.1K | -20,515 | Closed |
|
155
Los Angeles Capital Management
Los Angeles,
California
| – | -$48.5K | -20,196 | Closed |
|
156
State Board of Administration of Florida Retirement System
Tallahassee,
Florida
| – | -$37.5K | -15,607 | Closed |
|
|
EGM
157
Engineers Gate Manager
New York
| – | -$32.2K | -13,401 | Closed |
|
|
PAS
158
Point72 Asia (Singapore)
Singapore
| – | -$17.1K | -7,111 | Closed |
|
159
Simplex Trading
Chicago,
Illinois
| – | -$16.6K | -6,673 | Closed |
|
|
PD
160
Point72 (DIFC)
Dubai,
United Arab Emirates
| – | -$4.71K | -1,964 | Closed |
|
|
PWMG
161
Prestige Wealth Management Group
Flemington,
New Jersey
| – | -$444 | -185 | Closed |
|
ANNX Hedge Fund Activity: Q3 2025 in Review
144 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q3 2025, worth a combined $309M — up 30% from $239M a quarter earlier.
Buyers outnumbered sellers: 33 funds opened new ANNX positions and 17 closed out — a net gain of 16 holders — while 51 added to existing stakes and 36 trimmed.
The largest buyer was Opaleye Management, opening a new position worth an estimated $6.46M. The largest seller was Fidelity Investments, cutting an estimated $11.5M.
- 144 institutional investors held Annexon (ANNX) as of Q3 2025, up from 129 in Q2 2025.
- Funds reported $309M of Annexon stock for Q3 2025, up 30% quarter-over-quarter.
- 33 funds opened new Annexon positions in Q3 2025 and 17 closed out, a net change of +16 holders.
- The largest Annexon buyer in Q3 2025 was Opaleye Management, an estimated $6.46M added.
- The largest Annexon seller in Q3 2025 was Fidelity Investments, an estimated $11.5M sold.
Based on aggregated 13F filings for Q3 2025.