Annexon
ANNX
147 hedge funds and large institutions have $192M invested in Annexon in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 55 increasing their positions, 41 reducing their positions, and 28 closing their positions.
34% more repeat investments, than reductions
Existing positions increased: 55 | Existing positions reduced: 41
3% less funds holding
Funds holding: 152 → 147 (-5)
14% less first-time investments, than exits
New positions opened: 24 | Existing positions closed: 28
14.31% less ownership
Funds ownership: 105.23% → 90.92% (-14%)
22% less call options, than puts
Call options by funds: $127K | Put options by funds: $163K
67% less capital invested
Capital invested by funds: $575M → $192M (-$382M)
100% less funds holding in top 10
Funds holding in top 10: 3 → 0 (-3)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Ameriprise
Minneapolis,
Minnesota
|
+$10.2M |
| 2 |
LGM
Logos Global Management
San Francisco,
California
|
+$4.83M |
| 3 |
TAM
TFG Asset Management
Grand Cayman,
Cayman Islands
|
+$4.16M |
| 4 |
SCM
Sio Capital Management
New York
|
+$3.43M |
| 5 |
Bank of America
Charlotte,
North Carolina
|
+$3.36M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Point72 Asset Management
Stamford,
Connecticut
|
-$18.6M |
| 2 |
State Street
Boston,
Massachusetts
|
-$8.22M |
| 3 |
Nuveen
Charlotte,
North Carolina
|
-$7.9M |
| 4 |
EAM
Eventide Asset Management
Boston,
Massachusetts
|
-$5.22M |
| 5 |
RAM
Readystate Asset Management
Chicago,
Illinois
|
-$3.98M |
ANNX Hedge Fund Activity: Q1 2025 in Review
147 of the 7,471 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q1 2025, worth a combined $192M — down 67% from $575M a quarter earlier.
Sellers outnumbered buyers: 28 funds closed out of ANNX and 24 opened new positions — a net loss of 4 holders — while 41 trimmed existing stakes and 55 added.
The largest buyer was Ameriprise, adding an estimated $10.2M. The largest seller was Point72 Asset Management, cutting an estimated $18.6M.
- 147 institutional investors held Annexon (ANNX) as of Q1 2025, down from 152 in Q4 2024.
- Funds reported $192M of Annexon stock for Q1 2025, down 67% quarter-over-quarter.
- 24 funds opened new Annexon positions in Q1 2025 and 28 closed out, a net change of -4 holders.
- The largest Annexon buyer in Q1 2025 was Ameriprise, an estimated $10.2M added.
- The largest Annexon seller in Q1 2025 was Point72 Asset Management, an estimated $18.6M sold.
Based on aggregated 13F filings for Q1 2025.