Annexon
ANNX
129 hedge funds and large institutions have $239M invested in Annexon in 2025 Q2 according to their latest regulatory filings, with 20 funds opening new positions, 50 increasing their positions, 34 reducing their positions, and 37 closing their positions.
47% more repeat investments, than reductions
Existing positions increased: 50 | Existing positions reduced: 34
24% more capital invested
Capital invested by funds: $192M → $239M (+$46.6M)
0.03% less ownership
Funds ownership: 90.91% → 90.88% (-0.03%)
12% less funds holding
Funds holding: 146 → 129 (-17)
46% less first-time investments, than exits
New positions opened: 20 | Existing positions closed: 37
67% less call options, than puts
Call options by funds: $50K | Put options by funds: $153K
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
+$4.88M |
| 2 |
Millennium Management
New York
|
+$4.69M |
| 3 |
Goldman Sachs
New York
|
+$1.58M |
| 4 |
SCM
Sio Capital Management
New York
|
+$1.4M |
| 5 |
Bank of America
Charlotte,
North Carolina
|
+$830K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Ameriprise
Minneapolis,
Minnesota
|
-$3.65M |
| 2 |
LGM
Logos Global Management
San Francisco,
California
|
-$3.19M |
| 3 |
JP Morgan Chase
New York
|
-$2.76M |
| 4 |
WP
Woodline Partners
San Francisco,
California
|
-$2.13M |
| 5 |
BlackRock
New York
|
-$1.13M |
ANNX Hedge Fund Activity: Q2 2025 in Review
129 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q2 2025, worth a combined $239M — up 24% from $192M a quarter earlier.
Sellers outnumbered buyers: 37 funds closed out of ANNX and 20 opened new positions — a net loss of 17 holders — while 34 trimmed existing stakes and 50 added.
The largest buyer was Fidelity Investments, adding an estimated $4.88M. The largest seller was Ameriprise, cutting an estimated $3.65M.
- 129 institutional investors held Annexon (ANNX) as of Q2 2025, down from 146 in Q1 2025.
- Funds reported $239M of Annexon stock for Q2 2025, up 24% quarter-over-quarter.
- 20 funds opened new Annexon positions in Q2 2025 and 37 closed out, a net change of -17 holders.
- The largest Annexon buyer in Q2 2025 was Fidelity Investments, an estimated $4.88M added.
- The largest Annexon seller in Q2 2025 was Ameriprise, an estimated $3.65M sold.
Based on aggregated 13F filings for Q2 2025.