Annexon
ANNX
168 hedge funds and large institutions have $687M invested in Annexon in 2025 Q4 according to their latest regulatory filings, with 41 funds opening new positions, 72 increasing their positions, 30 reducing their positions, and 14 closing their positions.
193% more first-time investments, than exits
New positions opened: 41 | Existing positions closed: 14
140% more repeat investments, than reductions
Existing positions increased: 72 | Existing positions reduced: 30
122% more capital invested
Capital invested by funds: $309M → $687M (+$378M)
59% more call options, than puts
Call options by funds: $4.31M | Put options by funds: $2.71M
22.18% more ownership
Funds ownership: 92.26% → 114.44% (+22%)
17% more funds holding
Funds holding: 144 → 168 (+24)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Adage Capital Partners
Boston,
Massachusetts
|
+$15.3M |
| 2 |
RG
Redmile Group
San Francisco,
California
|
+$14.3M |
| 3 |
LP
Longaeva Partners
Chicago,
Illinois
|
+$11.9M |
| 4 |
MCO
MAK Capital One
New York
|
+$11.3M |
| 5 |
State Street
Boston,
Massachusetts
|
+$9.95M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
CS
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
-$7.73M |
| 2 |
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
-$3.61M |
| 3 |
Fidelity Investments
Boston,
Massachusetts
|
-$3.28M |
| 4 |
RPAM
Rhenman & Partners Asset Management
Stockholm,
Sweden
|
-$2.51M |
| 5 |
Goldman Sachs
New York
|
-$2.44M |
ANNX Hedge Fund Activity: Q4 2025 in Review
168 of the 8,270 institutional investors tracked by Wall St. Rank reported a position in Annexon (ANNX) for Q4 2025, worth a combined $687M — up 122% from $309M a quarter earlier.
Buyers outnumbered sellers: 41 funds opened new ANNX positions and 14 closed out — a net gain of 27 holders — while 72 added to existing stakes and 30 trimmed.
The largest buyer was Adage Capital Partners, adding an estimated $15.3M. The largest seller was Candriam SCA, exiting entirely with an estimated $7.73M sold.
- 168 institutional investors held Annexon (ANNX) as of Q4 2025, up from 144 in Q3 2025.
- Funds reported $687M of Annexon stock for Q4 2025, up 122% quarter-over-quarter.
- 41 funds opened new Annexon positions in Q4 2025 and 14 closed out, a net change of +27 holders.
- The largest Annexon buyer in Q4 2025 was Adage Capital Partners, an estimated $15.3M added.
- The largest Annexon seller in Q4 2025 was Candriam SCA, an estimated $7.73M sold.
Based on aggregated 13F filings for Q4 2025.