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Opaleye Management’s Annexon ANNX Stock Holding History

Opaleye Management’s Portfolio ANNX Stock Details ANNX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$12.9M Sell
2,331,761
-268,239
-10% -$1.51M 1.7% 18
2025
Q4 		$13.1M Hold
2,600,000
– – 1.72% 17
2025
Q3 		$7.93M Buy
+2,600,000
New +$6.46M 1.12% 21

Other funds holding ANNX

RG
Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
BCLSI
Bain Capital Life Sciences Investors Boston, Massachusetts $1.11B AUM 171.34% 1-Year Est. Return
BG
Bellevue Group Kuesnacht, Switzerland $4.2B AUM 54.85% 1-Year Est. Return
MCO
MAK Capital One New York $679M AUM 29.02% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return

Opaleye Management's ANNX Position: Q1 2026 in Review

Opaleye Management reduced its Annexon (ANNX) stake by 10% in Q1 2026, selling an estimated $1.51M and leaving 2,331,761 shares worth $12.9M. The position accounts for 1.7% of the portfolio, ranked #18.

Opaleye Management first reported a position in ANNX in Q3 2025 and has held it in 3 quarters since. The position peaked at $13.1M in Q4 2025. 217 funds tracked by Wall St. Rank hold ANNX as of Q1 2026.

  • Opaleye Management held 2,331,761 shares of Annexon worth $12.9M as of Q1 2026.
  • Opaleye Management sold 268,239 Annexon shares in Q1 2026, an estimated $1.51M.
  • Annexon made up 1.7% of Opaleye Management's portfolio in Q1 2026, its #18 holding.
  • Opaleye Management first reported a position in Annexon in Q3 2025 and has held it in 3 quarters since.
  • Opaleye Management's Annexon position peaked at $13.1M in Q4 2025.
  • 217 funds tracked by Wall St. Rank held Annexon as of Q1 2026.

Based on Opaleye Management's 13F filing for Q1 2026, filed 15 May 2026.