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Opaleye Management’s Annexon ANNX Stock Holding History

Opaleye Management’s Portfolio ANNX Stock Details ANNX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$9.79M Sell
1,714,451
-617,310
-26% -$3.41M 0.89% 28
2026
Q1 		$12.9M Sell
2,331,761
-268,239
-10% -$1.51M 1.7% 18
2025
Q4 		$13.1M Hold
2,600,000
– – 1.72% 17
2025
Q3 		$7.93M Buy
+2,600,000
New +$6.46M 1.12% 21

Other funds holding ANNX

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
RG
Redmile Group San Francisco, California $1.49B AUM 208.7% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return
WP
Woodline Partners San Francisco, California $32.4B AUM 58.5% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
MCO
MAK Capital One New York $714M AUM 68.07% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return

Opaleye Management's ANNX Position: Q2 2026 in Review

Opaleye Management reduced its Annexon (ANNX) stake by 26% in Q2 2026, selling an estimated $3.41M and leaving 1,714,451 shares worth $9.79M. The position accounts for 0.89% of the portfolio, ranked #28.

Opaleye Management first reported a position in ANNX in Q3 2025 and has held it in 4 quarters since. The position peaked at $13.1M in Q4 2025. 217 funds tracked by Wall St. Rank hold ANNX as of Q2 2026.

  • Opaleye Management held 1,714,451 shares of Annexon worth $9.79M as of Q2 2026.
  • Opaleye Management sold 617,310 Annexon shares in Q2 2026, an estimated $3.41M.
  • Annexon made up 0.89% of Opaleye Management's portfolio in Q2 2026, its #28 holding.
  • Opaleye Management first reported a position in Annexon in Q3 2025 and has held it in 4 quarters since.
  • Opaleye Management's Annexon position peaked at $13.1M in Q4 2025.
  • 217 funds tracked by Wall St. Rank held Annexon as of Q2 2026.

Based on Opaleye Management's 13F filing for Q2 2026, filed 14 Aug 2026.