AnaptysBio
ANAB
179 hedge funds and large institutions have $1.42B invested in AnaptysBio in 2025 Q4 according to their latest regulatory filings, with 37 funds opening new positions, 51 increasing their positions, 64 reducing their positions, and 24 closing their positions.
54% more first-time investments, than exits
New positions opened: 37 | Existing positions closed: 24
45% more capital invested
Capital invested by funds: $980M → $1.42B (+$443M)
8% more funds holding
Funds holding: 166 → 179 (+13)
7.11% less ownership
Funds ownership: 113.12% → 106.02% (-7.1%)
14% less call options, than puts
Call options by funds: $20.8M | Put options by funds: $24.2M
20% less funds holding in top 10
Funds holding in top 10: 5 → 4 (-1)
20% less repeat investments, than reductions
Existing positions increased: 51 | Existing positions reduced: 64
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
AAA
Affinity Asset Advisors
New York
|
+$17.3M |
| 2 |
D.E. Shaw & Co
New York
|
+$12.5M |
| 3 |
Voloridge Investment Management
Jupiter,
Florida
|
+$8.57M |
| 4 |
Arrowstreet Capital
Boston,
Massachusetts
|
+$7.38M |
| 5 |
State Street
Boston,
Massachusetts
|
+$7.02M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
-$27.5M |
| 2 |
Assenagon Asset Management
Senningerberg,
Luxembourg
|
-$25.7M |
| 3 |
Morgan Stanley
New York
|
-$20.3M |
| 4 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
-$19.1M |
| 5 |
FLAM
First Light Asset Management
Edina,
Minnesota
|
-$13.4M |
ANAB Hedge Fund Activity: Q4 2025 in Review
179 of the 8,266 institutional investors tracked by Wall St. Rank reported a position in AnaptysBio (ANAB) for Q4 2025, worth a combined $1.42B — up 45% from $980M a quarter earlier.
Buyers outnumbered sellers: 37 funds opened new ANAB positions and 24 closed out — a net gain of 13 holders — while 51 added to existing stakes and 64 trimmed.
The largest buyer was Affinity Asset Advisors, opening a new position worth an estimated $17.3M. The largest seller was Millennium Management, cutting an estimated $27.5M.
- 179 institutional investors held AnaptysBio (ANAB) as of Q4 2025, up from 166 in Q3 2025.
- Funds reported $1.42B of AnaptysBio stock for Q4 2025, up 45% quarter-over-quarter.
- 37 funds opened new AnaptysBio positions in Q4 2025 and 24 closed out, a net change of +13 holders.
- The largest AnaptysBio buyer in Q4 2025 was Affinity Asset Advisors, an estimated $17.3M added.
- The largest AnaptysBio seller in Q4 2025 was Millennium Management, an estimated $27.5M sold.
Based on aggregated 13F filings for Q4 2025.