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Amylyx Pharmaceuticals

177 hedge funds and large institutions have $1.36B invested in Amylyx Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 39 funds opening new positions, 70 increasing their positions, 44 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

9% less capital invested

Capital invested by funds: $1.49B → $1.36B (-$135M)

20.82% less ownership

Funds ownership: 123.05%102.23% (-21%)

33% less funds holding in top 10

Funds holding in top 10: 96 (-3)

Holders
177
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
6
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$6.39M
Puts
$1.21M
Net Calls
Net Calls Change

Top Buyers

1 +$69.8M
2 +$26.2M
3 +$26M
4
CC
Commodore Capital
New York
+$21.4M
5
Franklin Resources
Franklin Resources
California
+$16.3M
Name Holding Trade Value Shares
Change
Change in
Stake
SPIA
151
Steward Partners Investment Advisory
New York
$18.1K
SOW
152
State of Wyoming
Wyoming
$16.7K
BNP Paribas Asset Management
153
BNP Paribas Asset Management
France
$16K
Carson Wealth (CWM LLC)
154
Carson Wealth (CWM LLC)
Nebraska
$14K
Los Angeles Capital Management
155
Los Angeles Capital Management
California
$12K
Nisa Investment Advisors
156
Nisa Investment Advisors
Missouri
$11.1K
WA
157
Westfuller Advisors
New York
$9.89K
DF
158
Dunhill Financial
United Kingdom
$7.25K
PNC Financial Services Group
159
PNC Financial Services Group
Pennsylvania
$5.29K
PWA
160
Physician Wealth Advisors
Utah
$3.31K
GI
161
GAMMA Investing
California
$3.23K
Rockefeller Capital Management
162
Rockefeller Capital Management
New York
$3.15K
Osaic Holdings
163
Osaic Holdings
Arizona
$3.01K
Daiwa Securities Group
164
Daiwa Securities Group
Japan
$3K
EWM
165
Evolution Wealth Management
Florida
$1.99K
MPWT
166
MassMutual Private Wealth & Trust
Connecticut
$1.85K
JSAM
167
J. Safra Asset Management
New York
$1.49K
HI
168
Harbour Investments
Wisconsin
$1.09K
CAIM
169
Catherine Avery Investment Management
Florida
$1.05K
LFG
170
Larson Financial Group
Missouri
$495
Jones Financial Companies
171
Jones Financial Companies
Missouri
$362
FC
172
Financial Consulate
Maryland
$302
EWA
173
EverSource Wealth Advisors
Alabama
$302
FFA
174
Farther Finance Advisors
California
$242
AF
175
Allworth Financial
California
$145