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Amylyx Pharmaceuticals

177 hedge funds and large institutions have $1.36B invested in Amylyx Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 39 funds opening new positions, 70 increasing their positions, 44 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

9% less capital invested

Capital invested by funds: $1.49B → $1.36B (-$135M)

20.82% less ownership

Funds ownership: 123.05%102.23% (-21%)

33% less funds holding in top 10

Funds holding in top 10: 96 (-3)

Holders
177
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
6
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$6.39M
Puts
$1.21M
Net Calls
Net Calls Change

Top Buyers

1 +$69.8M
2 +$26.2M
3 +$26M
4
CC
Commodore Capital
New York
+$21.4M
5
Franklin Resources
Franklin Resources
California
+$16.3M
Name Holding Trade Value Shares
Change
Change in
Stake
AQR Capital Management
101
AQR Capital Management
Connecticut
$336K
IQI
102
Integrated Quantitative Investments
Washington
$329K
Manulife (Manufacturers Life Insurance)
103
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$326K
GC
104
Guggenheim Capital
Illinois
$305K
BNP Paribas Financial Markets
105
BNP Paribas Financial Markets
France
$304K
ACM
106
Aquatic Capital Management
Illinois
$294K
PFSRSONJ
107
Police & Firemen's Retirement System of New Jersey
New Jersey
$287K
ASRS
108
Arizona State Retirement System
Arizona
$277K
Tudor Investment Corp
109
Tudor Investment Corp
Connecticut
$271K
New York State Common Retirement Fund
110
New York State Common Retirement Fund
New York
$265K
PCM
111
Parsons Capital Management
Rhode Island
$261K
ProShare Advisors
112
ProShare Advisors
Maryland
$255K
SSA
113
Schonfeld Strategic Advisors
New York
$254K
SG Americas Securities
114
SG Americas Securities
New York
$252K
VPIM
115
Vanguard Personalized Indexing Management
California
$252K
PA
116
Profund Advisors
Maryland
$249K
VIA
117
Virtus Investment Advisers
Connecticut
$245K
PPWP
118
Premier Path Wealth Partners
New Jersey
$245K
Brown Advisory
119
Brown Advisory
Maryland
$241K
EGM
120
Engineers Gate Manager
New York
$222K
CUAMC
121
China Universal Asset Management Company
China
$216K
Rafferty Asset Management
122
Rafferty Asset Management
New York
$213K
KK
123
KLP Kapitalforvaltning
Norway
$210K
JAM
124
Jupiter Asset Management
United Kingdom
$188K
Royal Bank of Canada
125
Royal Bank of Canada
Ontario, Canada
$188K