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Amylyx Pharmaceuticals
AMLX

Overview Fund Activity

130 hedge funds and large institutions have $524M invested in Amylyx Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 32 funds opening new positions, 37 increasing their positions, 37 reducing their positions, and 36 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
130
Holders Change
-4
Holders Change %
-2.99%
% of All Funds
1.74%
Holding in Top 10
6
Holding in Top 10 Change
+5
Holding in Top 10 Change %
+500%
% of All Funds
0.08%
New
32
Increased
37
Reduced
37
Closed
36
Calls
$1.48M
Puts
$103K
Net Calls
+$1.38M
Net Calls Change
+$1.46M

Top Buyers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
$29.1M
2
BlackRock
BlackRock
New York
$35.3M
3
Adage Capital Partners
Adage Capital Partners
Massachusetts
$56.4M
4
Fidelity Investments
Fidelity Investments
Massachusetts
$19.5M
5
DCM
Driehaus Capital Management
Illinois
$8.11M

Top Sellers

1
Aberdeen Group
Aberdeen Group
United Kingdom
$4.73M
2
Millennium Management
Millennium Management
New York
$9.69M
3
Citadel Advisors
Citadel Advisors
Florida
$7.97M
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$711K
5
Goldman Sachs
Goldman Sachs
New York
$8.32M
Name Holding Trade Value Shares
Change 		Shares
Change %
NL
51
Nuveen LLC
North Carolina
$997K +$997K +155,536 New
D.E. Shaw & Co
52
D.E. Shaw & Co
New York
$971K -$760K -118,504 -44%
Bank of New York Mellon
53
Bank of New York Mellon
New York
$967K +$967K +150,837 New
Bank of Montreal
54
Bank of Montreal
Ontario, Canada
$920K – – –
American Century Companies
55
American Century Companies
Missouri
$861K +$175K +27,366 +26%
Barclays
56
Barclays
United Kingdom
$835K -$45.7K -7,131 -5%
CSS
57
Cubist Systematic Strategies
Connecticut
$790K +$257K +40,112 +48%
AI
58
Allostery Investments
Connecticut
$770K -$936K -145,980 -55%
Susquehanna International Group
59
Susquehanna International Group
Pennsylvania
$711K -$8.72M -1,360,079 -92%
RhumbLine Advisers
60
RhumbLine Advisers
Massachusetts
$645K +$645K +100,576 New
TCM
61
Tang Capital Management
California
$641K – – –
EI
62
EAM Investors
California
$641K +$641K +99,960 New
Ameriprise
63
Ameriprise
Minnesota
$610K +$528K +82,414 +644%
KCM
64
Kennondale Capital Management
Virginia
$610K -$690K -107,578 -53%
T. Rowe Price Associates
65
T. Rowe Price Associates
Maryland
$586K +$216K +33,692 +58%
JPMorgan Chase & Co
66
JPMorgan Chase & Co
New York
$564K +$217K +33,920 +63%
HWAM
67
Hennion & Walsh Asset Management
New Jersey
$364K -$169K -26,405 -32%
CF
68
Cantor Fitzgerald
New York
$321K -$321K -50,000 -50%
Mariner
69
Mariner
Kansas
$312K -$14.3K -2,238 -4%
JF
70
Jump Financial
Illinois
$306K +$306K +47,800 New
CC
71
Centiva Capital
New York
$291K +$111K +17,242 +61%
MIM
72
MetLife Investment Management
New Jersey
$275K +$275K +42,929 New
Squarepoint
73
Squarepoint
New York
$261K -$226K -35,206 -46%
Wells Fargo
74
Wells Fargo
California
$244K +$242K +37,801 +12,600%
Mirae Asset Global ETFs Holdings
75
Mirae Asset Global ETFs Holdings
Hong Kong
$243K +$243K +37,987 New
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