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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
Daiwa Securities Group
201
Daiwa Securities Group
Japan
$10.3M
IMRF
202
Illinois Municipal Retirement Fund
Illinois
$10.2M
QCM
203
Quantinno Capital Management
New York
$10.2M
Assenagon Asset Management
204
Assenagon Asset Management
Luxembourg
$10.2M
Carson Wealth (CWM LLC)
205
Carson Wealth (CWM LLC)
Nebraska
$10.1M
Macquarie Group
206
Macquarie Group
Australia
$10.1M
CUAMC
207
China Universal Asset Management Company
China
$10M
MMC
208
Mizuho Markets Cayman
Cayman Islands
$9.92M
Brown Advisory
209
Brown Advisory
Maryland
$9.88M
Cerity Partners
210
Cerity Partners
New York
$9.77M
ECSS
211
Eurizon Capital SGR SpA
$9.71M
Creative Planning
212
Creative Planning
Kansas
$9.47M
Corient Private Wealth
213
Corient Private Wealth
Florida
$9.4M
BCIM
214
British Columbia Investment Management
British Columbia, Canada
$9.23M
Toronto Dominion Bank
215
Toronto Dominion Bank
Ontario, Canada
$9.23M
SLAM
216
Swiss Life Asset Management
$8.94M
Nomura Holdings
217
Nomura Holdings
Japan
$8.92M
BBVA
218
Banco Bilbao Vizcaya Argentaria
Spain
$8.72M
Credit Agricole
219
Credit Agricole
France
$8.57M
IMCOOI
220
Investment Management Corp of Ontario (IMCO)
Canada
$8.56M
Acadian Asset Management
221
Acadian Asset Management
Massachusetts
$8.47M
APM
222
Avidity Partners Management
Texas
$8.35M
Capital Fund Management (CFM)
223
Capital Fund Management (CFM)
France
$8.33M
URS
224
Utah Retirement Systems
Utah
$8.24M
Thrivent Financial for Lutherans
225
Thrivent Financial for Lutherans
Minnesota
$8.21M