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Alnylam Pharmaceuticals

833 hedge funds and large institutions have $51.6B invested in Alnylam Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 160 funds opening new positions, 284 increasing their positions, 290 reducing their positions, and 115 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less ownership

Funds ownership:

2% less repeat investments, than reductions

Existing positions increased: 284 | Existing positions reduced: 290

13% less capital invested

Capital invested by funds: $59.2B → $51.6B (-$7.56B)

69% less funds holding in top 10

Funds holding in top 10: 134 (-9)

Holders
833
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$760M
Puts
$448M
Net Calls
Net Calls Change

Top Buyers

1 +$303M
2 +$220M
3 +$158M
4
UBS Group
UBS Group
Switzerland
+$149M
5
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$108M

Top Sellers

1 -$635M
2 -$383M
3 -$360M
4
Jane Street
Jane Street
New York
-$287M
5
Macquarie Group
Macquarie Group
Australia
-$276M
Name Holding Trade Value Shares
Change
Change in
Stake
NAM
176
Nissay Asset Management
Japan
$14.2M
Lord, Abbett & Co
177
Lord, Abbett & Co
New Jersey
$14.1M
PPF
178
PFA Pension Forsikringsaktieselskab
$14.1M
Bank of Montreal
179
Bank of Montreal
Ontario, Canada
$14M
EAM
180
Eventide Asset Management
Massachusetts
$13.5M
RSS
181
Rosenblum Silverman Sutton
California
$13.2M
TRSOTSOK
182
Teachers Retirement System of the State of Kentucky
Kentucky
$12.6M
PAM
183
Panagora Asset Management
Massachusetts
$12.3M
DnB Asset Management
184
DnB Asset Management
Norway
$12.2M
JF
185
Jump Financial
Illinois
$12.2M
GFM
186
GF Fund Management
China
$12.1M
ZIG
187
Zurich Insurance Group
Switzerland
$12.1M
FAF
188
Fjarde Ap-fonden
Sweden
$12M
OBAM
189
ODDO BHF Asset Management
France
$12M
CIBC Asset Management
190
CIBC Asset Management
Ontario, Canada
$11.9M
SO
191
STRS Ohio
Ohio
$11.1M
USCWA
192
U.S. Capital Wealth Advisors
Texas
$10.9M
X
193
Xponance
Pennsylvania
$10.9M
TI
194
Trexquant Investment
Connecticut
$10.6M
EI
195
EFG International
$10.5M
JFG
196
Jefferies Financial Group
New York
$10.5M
II
197
IFM Investors
Australia
$10.4M
UIM
198
USS Investment Management
United Kingdom
$10.4M
VMPIC
199
Varma Mutual Pension Insurance Co
Finland
$10.4M
EAM
200
Erste Asset Management
Austria
$10.4M