|
1
|
BVF Inc
San Francisco,
California
|
US$ 323 mi
|
+US$ 203 mi
|
+5.003.000
|
+193%
|
|
|
2
|
|
US$ 72,1 mi
|
-US$ 202 mil
|
-4.990
|
-0,3%
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
US$ 68,2 mi
|
+US$ 12,3 mi
|
+302.558
|
+23%
|
|
|
4
|
Woodline Partners
San Francisco,
California
|
US$ 47,4 mi
|
+US$ 19,2 mi
|
+474.362
|
+74%
|
|
|
5
|
Newtyn Management
New York
|
US$ 30,1 mi
|
+US$ 28,8 mi
|
+709.247
|
Nova
|
|
|
6
|
|
US$ 29,4 mi
|
+US$ 1,83 mi
|
+45.057
|
+7%
|
|
|
7
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
US$ 21,5 mi
|
-US$ 1,81 mi
|
-44.631
|
-8%
|
|
|
8
|
Opaleye Management
Boston,
Massachusetts
|
US$ 14,4 mi
|
+US$ 1,56 mi
|
+38.374
|
+13%
|
|
|
9
|
Geode Capital Management
Boston,
Massachusetts
|
US$ 10,4 mi
|
+US$ 631 mil
|
+15.555
|
+7%
|
|
|
10
|
Water Island Capital
New York
|
US$ 10,3 mi
|
+US$ 9,8 mi
|
+242.000
|
Nova
|
|
|
11
|
Alpine Associates Management
Palm Beach,
Florida
|
US$ 10,2 mi
|
+US$ 9,7 mi
|
+239.318
|
Nova
|
|
|
12
|
State Street
Boston,
Massachusetts
|
US$ 8,4 mi
|
+US$ 187 mil
|
+4.616
|
+2%
|
|
|
13
|
Millennium Management
New York
|
US$ 8,34 mi
|
-US$ 349 mil
|
-8.613
|
-4%
|
|
|
14
|
Dimensional Fund Advisors
Austin,
Texas
|
US$ 7,53 mi
|
+US$ 1,77 mi
|
+43.746
|
+33%
|
|
|
15
|
HSBC Holdings
London,
United Kingdom
|
US$ 6,31 mi
|
+US$ 6,06 mi
|
+149.523
|
Nova
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
US$ 4,09 mi
|
+US$ 109 mil
|
+2.689
|
+3%
|
|
|
17
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
US$ 3,84 mi
|
+US$ 185 mil
|
+4.551
|
+5%
|
|
|
18
|
Tudor Investment Corp
Stamford,
Connecticut
|
US$ 3,59 mi
|
+US$ 3,42 mi
|
+84.391
|
Nova
|
|
|
19
|
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
US$ 3,55 mi
|
+US$ 2,69 mi
|
+66.233
|
+381%
|
|
|
20
|
Torno Capital
Cohasset,
Massachusetts
|
US$ 3,4 mi
|
+US$ 3,24 mi
|
+80.000
|
Nova
|
|
|
21
|
Bank of New York Mellon
New York
|
US$ 3,2 mi
|
+US$ 14,8 mil
|
+364
|
+0,5%
|
|
|
22
|
Verition Fund Management
Greenwich,
Connecticut
|
US$ 3 mi
|
+US$ 2,86 mi
|
+70.601
|
Nova
|
|
|
23
|
Vanguard Fiduciary Trust
Malvern,
Pennsylvania
|
US$ 2,98 mi
|
+US$ 143 mil
|
+3.525
|
+5%
|
|
|
24
|
Simcoe Capital
Spokane,
Washington
|
US$ 2,89 mi
|
–
|
–
|
–
|
|
|
25
|
TLS Advisors
Miami,
Florida
|
US$ 1,79 mi
|
-US$ 2,95 mi
|
-72.702
|
-63%
|
|
