|
1
|
BVF Inc
San Francisco,
California
|
323 Mio. $
|
+203 Mio. $
|
+5.003.000
|
+193 %
|
|
|
2
|
|
72,1 Mio. $
|
-202.333 $
|
-4.990
|
-0,3 %
|
|
|
3
|
Fidelity Investments
Boston,
Massachusetts
|
68,2 Mio. $
|
+12,3 Mio. $
|
+302.558
|
+23 %
|
|
|
4
|
Woodline Partners
San Francisco,
California
|
47,4 Mio. $
|
+19,2 Mio. $
|
+474.362
|
+74 %
|
|
|
5
|
Newtyn Management
New York
|
30,1 Mio. $
|
+28,8 Mio. $
|
+709.247
|
Neu
|
|
|
6
|
|
29,4 Mio. $
|
+1,83 Mio. $
|
+45.057
|
+7 %
|
|
|
7
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
21,5 Mio. $
|
-1,81 Mio. $
|
-44.631
|
-8 %
|
|
|
8
|
Opaleye Management
Boston,
Massachusetts
|
14,4 Mio. $
|
+1,56 Mio. $
|
+38.374
|
+13 %
|
|
|
9
|
Geode Capital Management
Boston,
Massachusetts
|
10,4 Mio. $
|
+630.718 $
|
+15.555
|
+7 %
|
|
|
10
|
Water Island Capital
New York
|
10,3 Mio. $
|
+9,8 Mio. $
|
+242.000
|
Neu
|
|
|
11
|
Alpine Associates Management
Palm Beach,
Florida
|
10,2 Mio. $
|
+9,7 Mio. $
|
+239.318
|
Neu
|
|
|
12
|
State Street
Boston,
Massachusetts
|
8,4 Mio. $
|
+187.168 $
|
+4.616
|
+2 %
|
|
|
13
|
Millennium Management
New York
|
8,34 Mio. $
|
-349.236 $
|
-8.613
|
-4 %
|
|
|
14
|
Dimensional Fund Advisors
Austin,
Texas
|
7,53 Mio. $
|
+1,77 Mio. $
|
+43.746
|
+33 %
|
|
|
15
|
HSBC Holdings
London,
United Kingdom
|
6,31 Mio. $
|
+6,06 Mio. $
|
+149.523
|
Neu
|
|
|
16
|
Northern Trust
Chicago,
Illinois
|
4,09 Mio. $
|
+109.032 $
|
+2.689
|
+3 %
|
|
|
17
|
Vanguard Portfolio Management
Malvern,
Pennsylvania
|
3,84 Mio. $
|
+184.532 $
|
+4.551
|
+5 %
|
|
|
18
|
Tudor Investment Corp
Stamford,
Connecticut
|
3,59 Mio. $
|
+3,42 Mio. $
|
+84.391
|
Neu
|
|
|
19
|
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
3,55 Mio. $
|
+2,69 Mio. $
|
+66.233
|
+381 %
|
|
|
20
|
Torno Capital
Cohasset,
Massachusetts
|
3,4 Mio. $
|
+3,24 Mio. $
|
+80.000
|
Neu
|
|
|
21
|
Bank of New York Mellon
New York
|
3,2 Mio. $
|
+14.759 $
|
+364
|
+0,5 %
|
|
|
22
|
Verition Fund Management
Greenwich,
Connecticut
|
3 Mio. $
|
+2,86 Mio. $
|
+70.601
|
Neu
|
|
|
23
|
Vanguard Fiduciary Trust
Malvern,
Pennsylvania
|
2,98 Mio. $
|
+142.930 $
|
+3.525
|
+5 %
|
|
|
24
|
Simcoe Capital
Spokane,
Washington
|
2,89 Mio. $
|
–
|
–
|
–
|
|
|
25
|
TLS Advisors
Miami,
Florida
|
1,79 Mio. $
|
-2,95 Mio. $
|
-72.702
|
-63 %
|
|
