Two Sigma Securities’s Spero Therapeutics SPRO Stock Holding History

Two Sigma Securities’s Portfolio SPRO Stock Details SPRO Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$23.4K	Buy	+10,576	New	+$27.7K	﹤0.01%	1472
2024 Q3	–	Sell	-67,728	Closed	-$88K	–	3583
2024 Q2	$88K	Buy	+67,728	New	+$102K	﹤0.01%	2502
2024 Q1	–	Sell	-10,301	Closed	-$15.1K	–	3605
2023 Q4	$15.1K	Buy	+10,301	New	+$12.3K	﹤0.01%	2764
2023 Q1	–	Sell	-23,523	Closed	-$40.7K	–	3232
2022 Q4	$40.7K	Buy	+23,523	New	+$43.9K	﹤0.01%	2190

Other funds holding SPRO

GSK plc London $602M AUM

Pfizer New York $170M AUM 191.09% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Renaissance Technologies New York $72.6B AUM 54.88% 1-Year Est. Return

Alphabet Inc Mountain View, California $99.1B AUM 124.46% 1-Year Est. Return

Susquehanna International Group Bala Cynwyd, Pennsylvania $1.28T AUM 58.89% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return

Raymond James Financial St Petersburg, Florida $369B AUM 28.27% 1-Year Est. Return

Two Sigma Investments New York $138B AUM 41.87% 1-Year Est. Return

Two Sigma Securities's SPRO Position: Q2 2026 in Review

Two Sigma Securities opened a new position in Spero Therapeutics (SPRO) in Q2 2026: 10,576 shares worth $23.4K. The stake represents ﹤0.01% of the portfolio and ranks #1472 among its holdings. This is a return to the name: Two Sigma Securities previously reported a position in SPRO as recently as Q2 2024.

Two Sigma Securities first reported a position in SPRO in Q4 2022 and has held it in 4 quarters since. The position peaked at $88K in Q2 2024. 60 funds tracked by Wall St. Rank hold SPRO as of Q2 2026.

Two Sigma Securities held 10,576 shares of Spero Therapeutics worth $23.4K as of Q2 2026.
Spero Therapeutics was a new Two Sigma Securities position in Q2 2026.
Spero Therapeutics made up ﹤0.01% of Two Sigma Securities's portfolio in Q2 2026, its #1472 holding.
Two Sigma Securities first reported a position in Spero Therapeutics in Q4 2022 and has held it in 4 quarters since.
Two Sigma Securities's Spero Therapeutics position peaked at $88K in Q2 2024.
60 funds tracked by Wall St. Rank held Spero Therapeutics as of Q2 2026.

Based on Two Sigma Securities's 13F filing for Q2 2026, filed 14 Aug 2026.