Two Sigma Investments’s State Street SPDR S&P Biotech ETF XBI Stock Holding History

Two Sigma Investments’s Portfolio XBI Stock Details XBI Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2022 Q1	–	Sell	-15,200	Closed	-$1.7M	–	4494
2021 Q4	$1.7M	Sell	15,200 -23,900	-61%	-$2.88M	﹤0.01%	2071
2021 Q3	$4.92M	Sell	39,100 -8,100	-17%	-$1.04M	0.01%	1241
2021 Q2	$6.39M	Buy	47,200 +44,200	+1,473%	+$5.81M	0.01%	1053
2021 Q1	$407K	Buy	+3,000	New	+$449K	﹤0.01%	3106
2020 Q3	–	Sell	-14,300	Closed	-$1.6M	–	3625
2020 Q2	$1.6M	Sell	14,300 -7,100	-33%	-$699K	0.01%	1223
2020 Q1	$1.66M	Buy	+21,400	New	+$1.89M	0.01%	1074
2019 Q4	–	Sell	-85,000	Closed	-$6.48M	–	4028
2019 Q3	$6.48M	Buy	85,000 +15,500	+22%	+$1.29M	0.02%	742
2019 Q2	$6.1M	Buy	69,500 +56,500	+435%	+$4.82M	0.02%	811
2019 Q1	$1.18M	Sell	13,000 -56,000	-81%	-$4.76M	﹤0.01%	1723
2018 Q4	$4.95M	Sell	69,000 -15,500	-18%	-$1.25M	0.02%	805
2018 Q3	$8.1M	Buy	84,500 +3,800	+5%	+$368K	0.02%	734
2018 Q2	$7.68M	Buy	80,700 +55,700	+223%	+$5.12M	0.02%	789
2018 Q1	$2.19M	Buy	25,000 +14,000	+127%	+$1.28M	0.01%	1457
2017 Q4	$934K	Buy	+11,000	New	+$922K	﹤0.01%	2021

Other funds holding XBI

BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Citigroup New York $235B AUM 32.99% 1-Year Est. Return

Healthcare of Ontario Pension Plan (HOOPP) Trust Fund Toronto, Ontario, Canada $62.2B AUM 31.35% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

UBS Group Zurich, Switzerland $666B AUM 30.12% 1-Year Est. Return

Barclays London, United Kingdom $416B AUM 33.63% 1-Year Est. Return

Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return

Two Sigma Investments's XBI Position: Q1 2026 in Review

Two Sigma Investments reduced its State Street SPDR S&P Biotech ETF (XBI) stake by 81% in Q1 2026, selling an estimated $177M and leaving 341,169 shares worth $43.6M. The position accounts for 0.04% of the portfolio, ranked #551.

Two Sigma Investments first reported a position in XBI in Q3 2018 and has held it in 23 quarters since. The position peaked at $215M in Q4 2025. 814 funds tracked by Wall St. Rank hold XBI as of Q1 2026.

Two Sigma Investments held 341,169 shares of State Street SPDR S&P Biotech ETF worth $43.6M as of Q1 2026.
Two Sigma Investments sold 1,421,431 State Street SPDR S&P Biotech ETF shares in Q1 2026, an estimated $177M.
State Street SPDR S&P Biotech ETF made up 0.04% of Two Sigma Investments's portfolio in Q1 2026, its #551 holding.
Two Sigma Investments first reported a position in State Street SPDR S&P Biotech ETF in Q3 2018 and has held it in 23 quarters since.
Two Sigma Investments's State Street SPDR S&P Biotech ETF position peaked at $215M in Q4 2025.
814 funds tracked by Wall St. Rank held State Street SPDR S&P Biotech ETF as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.