Two Sigma Investments’s Vertex Pharmaceuticals VRTX Stock Holding History

Two Sigma Investments’s Portfolio VRTX Stock Details VRTX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$447K	Buy	+1,000	New	+$466K	﹤0.01%	3805
2017 Q2	–	Sell	-17,200	Closed	-$1.88M	–	3311
2017 Q1	$1.88M	Buy	+17,200	New	+$1.51M	0.01%	1497
2016 Q3	–	Sell	-8,000	Closed	-$688K	–	3409
2016 Q2	$688K	Buy	+8,000	New	+$691K	﹤0.01%	2021

Other funds holding VRTX

Capital World Investors Los Angeles, California $733B AUM 35.63% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Capital Research Global Investors Los Angeles, California $645B AUM 30.41% 1-Year Est. Return

VCM

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Invesco Atlanta, Georgia $1.02T AUM 30.18% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

VPM

Vanguard Portfolio Management Malvern, Pennsylvania $1.91T AUM

Capital International Investors Los Angeles, California $427B AUM 29.17% 1-Year Est. Return

Two Sigma Investments's VRTX Position: Q1 2026 in Review

Two Sigma Investments increased its Vertex Pharmaceuticals (VRTX) stake by 9,001% in Q1 2026, buying an estimated $174M and bringing the position to 378,146 shares worth $169M. The position accounts for 0.14% of the portfolio, ranked #168.

Two Sigma Investments first reported a position in VRTX in Q2 2015 and has held it in 34 quarters since. The position peaked at $174M in Q3 2021. 1,687 funds tracked by Wall St. Rank hold VRTX as of Q1 2026.

Two Sigma Investments held 378,146 shares of Vertex Pharmaceuticals worth $169M as of Q1 2026.
Two Sigma Investments bought 373,991 Vertex Pharmaceuticals shares in Q1 2026, an estimated $174M.
Vertex Pharmaceuticals made up 0.14% of Two Sigma Investments's portfolio in Q1 2026, its #168 holding.
Two Sigma Investments first reported a position in Vertex Pharmaceuticals in Q2 2015 and has held it in 34 quarters since.
Two Sigma Investments's Vertex Pharmaceuticals position peaked at $174M in Q3 2021.
1,687 funds tracked by Wall St. Rank held Vertex Pharmaceuticals as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.