Two Sigma Investments’s Vertex Pharmaceuticals VRTX Stock Holding History
Bought
Maintained
Sold
| Quarter | Market Value | Status | Shares |
Change in Stake | Trade Value | Portfolio Weight | Portfolio Position | |
|---|---|---|---|---|---|---|---|---|
|
2026
Q1 | $169M | Buy |
378,146
+373,991
| +9,001% | +$174M | 0.14% | 168 |
|
|
2025
Q4 | $1.88M | Buy |
+4,155
| New | +$1.79M | ﹤0.01% | 2476 |
|
|
2025
Q2 | – | Sell |
-4,121
| Closed | -$2M | – | 3564 |
|
|
2025
Q1 | $2M | Sell |
4,121
-29,039
| -88% | -$13.5M | ﹤0.01% | 1741 |
|
|
2024
Q4 | $13.4M | Sell |
33,160
-127,375
| -79% | -$59M | 0.03% | 633 |
|
|
2024
Q3 | $74.7M | Sell |
160,535
-171,452
| -52% | -$82.4M | 0.16% | 147 |
|
|
2024
Q2 | $156M | Buy |
331,987
+7,559
| +2% | +$3.28M | 0.35% | 61 |
|
|
2024
Q1 | $136M | Buy |
324,428
+188,254
| +138% | +$79.6M | 0.32% | 71 |
|
|
2023
Q4 | $55.4M | Sell |
136,174
-123,255
| -48% | -$45.5M | 0.13% | 204 |
|
|
2023
Q3 | $90.2M | Sell |
259,429
-129,454
| -33% | -$45.3M | 0.24% | 109 |
|
|
2023
Q2 | $137M | Buy |
388,883
+297,628
| +326% | +$100M | 0.34% | 65 |
|
|
2023
Q1 | $28.8M | Buy |
91,255
+62,133
| +213% | +$18.6M | 0.08% | 287 |
|
|
2022
Q4 | $8.41M | Buy |
+29,122
| New | +$8.88M | 0.03% | 628 |
|
|
2022
Q2 | – | Sell |
-33,644
| Closed | -$8.78M | – | 2967 |
|
|
2022
Q1 | $8.78M | Buy |
+33,644
| New | +$7.98M | 0.03% | 658 |
|
|
2021
Q4 | – | Sell |
-959,684
| Closed | -$174M | – | 4934 |
|
|
2021
Q3 | $174M | Buy |
+959,684
| New | +$187M | 0.39% | 46 |
|
|
2020
Q3 | – | Sell |
-102,102
| Closed | -$29.6M | – | 3596 |
|
|
2020
Q2 | $29.6M | Sell |
102,102
-363,044
| -78% | -$98.4M | 0.15% | 149 |
|
|
2020
Q1 | $111M | Sell |
465,146
-328,323
| -41% | -$75.3M | 0.9% | 11 |
|
|
2019
Q4 | $174M | Buy |
793,469
+280,834
| +55% | +$56.8M | 0.52% | 28 |
|
|
2019
Q3 | $86.9M | Buy |
512,635
+95,464
| +23% | +$16.9M | 0.29% | 69 |
|
|
2019
Q2 | $76.5M | Sell |
417,171
-243,353
| -37% | -$42.5M | 0.26% | 91 |
|
|
2019
Q1 | $122M | Buy |
660,524
+253,455
| +62% | +$46.8M | 0.39% | 35 |
|
|
2018
Q4 | $67.5M | Sell |
407,069
-171,514
| -30% | -$29.7M | 0.26% | 79 |
|
|
2018
Q3 | $112M | Buy |
578,583
+464,469
| +407% | +$82.7M | 0.3% | 81 |
|
|
2018
Q2 | $19.4M | Buy |
114,114
+70,060
| +159% | +$10.9M | 0.06% | 422 |
|
|
2018
Q1 | $7.18M | Sell |
44,054
-868,670
| -95% | -$142M | 0.02% | 749 |
|
|
2017
Q4 | $137M | Buy |
912,724
+462,416
| +103% | +$68.5M | 0.45% | 28 |
|
|
2017
Q3 | $68.5M | Buy |
450,308
+60,238
| +15% | +$9.07M | 0.24% | 109 |
|
|
2017
Q2 | $50.3M | Sell |
390,070
-255,360
| -40% | -$30.7M | 0.18% | 140 |
|
|
2017
Q1 | $70.6M | Sell |
645,430
-381,425
| -37% | -$33.6M | 0.24% | 91 |
|
|
2016
Q4 | $75.6M | Buy |
1,026,855
+604,506
| +143% | +$49.2M | 0.29% | 69 |
|
|
2016
Q3 | $36.8M | Buy |
+422,349
| New | +$39.9M | 0.13% | 163 |
|
|
2016
Q2 | – | Sell |
-995,248
| Closed | -$86M | – | 3275 |
|
|
2016
Q1 | $79.1M | Buy |
995,248
+652,347
| +190% | +$59M | 0.38% | 52 |
|
|
2015
Q4 | $43.1M | Sell |
342,901
-87,650
| -20% | -$10.6M | 0.21% | 122 |
|
|
2015
Q3 | $44.8M | Buy |
430,551
+274,253
| +175% | +$35.2M | 0.23% | 125 |
|
|
2015
Q2 | $19.3M | Buy |
+156,298
| New | +$19.7M | 0.09% | 279 |
|
Other funds holding VRTX
VCM
VPM
Two Sigma Investments's VRTX Position: Q1 2026 in Review
Two Sigma Investments increased its Vertex Pharmaceuticals (VRTX) stake by 9,001% in Q1 2026, buying an estimated $174M and bringing the position to 378,146 shares worth $169M. The position accounts for 0.14% of the portfolio, ranked #168.
Two Sigma Investments first reported a position in VRTX in Q2 2015 and has held it in 34 quarters since. The position peaked at $174M in Q3 2021. 1,687 funds tracked by Wall St. Rank hold VRTX as of Q1 2026.
- Two Sigma Investments held 378,146 shares of Vertex Pharmaceuticals worth $169M as of Q1 2026.
- Two Sigma Investments bought 373,991 Vertex Pharmaceuticals shares in Q1 2026, an estimated $174M.
- Vertex Pharmaceuticals made up 0.14% of Two Sigma Investments's portfolio in Q1 2026, its #168 holding.
- Two Sigma Investments first reported a position in Vertex Pharmaceuticals in Q2 2015 and has held it in 34 quarters since.
- Two Sigma Investments's Vertex Pharmaceuticals position peaked at $174M in Q3 2021.
- 1,687 funds tracked by Wall St. Rank held Vertex Pharmaceuticals as of Q1 2026.
Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.