Two Sigma Investments
INSM icon

Two Sigma Investments’s Insmed INSM Stock Holding History

Two Sigma Investments’s Portfolio INSM Stock Details INSM Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$132M Buy
1,242,222
+1,005,205
+424% +$122M 0.1% 234
2026
Q1 		$38.8M Sell
237,017
-725,139
-75% -$111M 0.03% 608
2025
Q4 		$167M Buy
962,156
+189,376
+25% +$34.6M 0.24% 105
2025
Q3 		$111M Buy
772,780
+396,272
+105% +$48.5M 0.17% 166
2025
Q2 		$37.9M Sell
376,508
-30,395
-7% -$2.32M 0.07% 356
2025
Q1 		$31M Sell
406,903
-187,093
-31% -$14.3M 0.07% 349
2024
Q4 		$41M Sell
593,996
-207,143
-26% -$14.9M 0.09% 278
2024
Q3 		$58.5M Buy
801,139
+693,395
+644% +$51.2M 0.13% 195
2024
Q2 		$7.22M Sell
107,744
-352,429
-77% -$13.7M 0.02% 843
2024
Q1 		$12.5M Buy
460,173
+107,561
+31% +$3.01M 0.03% 577
2023
Q4 		$10.9M Sell
352,612
-241,548
-41% -$6.26M 0.03% 644
2023
Q3 		$15M Buy
594,160
+105,388
+22% +$2.41M 0.04% 460
2023
Q2 		$10.3M Buy
488,772
+32,052
+7% +$608K 0.03% 634
2023
Q1 		$7.79M Buy
456,720
+1,684
+0.4% +$32.7K 0.02% 695
2022
Q4 		$9.09M Buy
455,036
+158,416
+53% +$3.06M 0.03% 595
2022
Q3 		$6.39M Buy
+296,620
New +$7.11M 0.02% 661
2022
Q2 		– Sell
-27,800
Closed -$653K – 2715
2022
Q1 		$653K Buy
27,800
+300
+1% +$6.97K ﹤0.01% 1889
2021
Q4 		$749K Sell
27,500
-307,709
-92% -$8.8M ﹤0.01% 2829
2021
Q3 		$9.23M Buy
335,209
+62,074
+23% +$1.63M 0.02% 810
2021
Q2 		$7.77M Buy
273,135
+48,588
+22% +$1.44M 0.02% 951
2021
Q1 		$7.65M Buy
224,547
+210,911
+1,547% +$8.06M 0.02% 829
2020
Q4 		$454K Sell
13,636
-202,326
-94% -$7.39M ﹤0.01% 2583
2020
Q3 		$6.94M Buy
215,962
+57,671
+36% +$1.66M 0.02% 650
2020
Q2 		$4.36M Buy
158,291
+111,736
+240% +$2.65M 0.02% 703
2020
Q1 		$746K Sell
46,555
-5,241
-10% -$124K 0.01% 1644
2019
Q4 		$1.24M Sell
51,796
-191,141
-79% -$3.89M ﹤0.01% 1999
2019
Q3 		$4.29M Sell
242,937
-218,674
-47% -$4.22M 0.01% 948
2019
Q2 		$11.8M Buy
461,611
+369,120
+399% +$10.3M 0.04% 527
2019
Q1 		$2.69M Buy
92,491
+57,979
+168% +$1.5M 0.01% 1253
2018
Q4 		$453K Sell
34,512
-3,967
-10% -$63.3K ﹤0.01% 2172
2018
Q3 		$778K Buy
38,479
+28,937
+303% +$653K ﹤0.01% 2156
2018
Q2 		$226K Sell
9,542
-86,343
-90% -$2.22M ﹤0.01% 3081
2018
Q1 		$2.16M Sell
95,885
-20,242
-17% -$533K 0.01% 1475
2017
Q4 		$3.62M Sell
116,127
-48,014
-29% -$1.42M 0.01% 1062
2017
Q3 		$5.12M Buy
164,141
+141,502
+625% +$2.7M 0.02% 786
2017
Q2 		$388K Buy
+22,639
New +$387K ﹤0.01% 2506
2013
Q4 		– Sell
-13,873
Closed -$217K – 2268
2013
Q3 		$217K Sell
13,873
-124,069
-90% -$1.58M ﹤0.01% 1610
2013
Q2 		$1.65M Buy
+137,942
New +$1.41M 0.01% 946

Other funds holding INSM

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Portfolio Management
Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM
JP Morgan Chase
JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
BBA
Baker Bros. Advisors New York $20B AUM 154.41% 1-Year Est. Return
Capital International Investors
Capital International Investors Los Angeles, California $484B AUM 34.9% 1-Year Est. Return
DGM
Darwin Global Management St. Helier, Jersey $3.76B AUM 342.13% 1-Year Est. Return
Ameriprise
Ameriprise Minneapolis, Minnesota $495B AUM 43.24% 1-Year Est. Return
OAG
Orbis Allan Gray Hamilton, Bermuda $29.1B AUM 60.8% 1-Year Est. Return

Two Sigma Investments's INSM Position: Q2 2026 in Review

Two Sigma Investments increased its Insmed (INSM) stake by 424% in Q2 2026, buying an estimated $122M and bringing the position to 1,242,222 shares worth $132M. The position accounts for 0.1% of the portfolio, ranked #234.

Two Sigma Investments first reported a position in INSM in Q2 2013 and has held it in 38 quarters since. The position peaked at $167M in Q4 2025. 663 funds tracked by Wall St. Rank hold INSM as of Q2 2026.

  • Two Sigma Investments held 1,242,222 shares of Insmed worth $132M as of Q2 2026.
  • Two Sigma Investments bought 1,005,205 Insmed shares in Q2 2026, an estimated $122M.
  • Insmed made up 0.1% of Two Sigma Investments's portfolio in Q2 2026, its #234 holding.
  • Two Sigma Investments first reported a position in Insmed in Q2 2013 and has held it in 38 quarters since.
  • Two Sigma Investments's Insmed position peaked at $167M in Q4 2025.
  • 663 funds tracked by Wall St. Rank held Insmed as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.