Two Sigma Investments’s Edgewise Therapeutics EWTX Stock Holding History

Two Sigma Investments’s Portfolio EWTX Stock Details EWTX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$2.01M	Sell	49,548 -1,300	-3%	-$44.8K	﹤0.01%	2994
2026 Q1	$1.6M	Hold	50,848	–	–	﹤0.01%	2930
2025 Q4	$1.26M	Buy	50,848 +24,582	+94%	+$493K	﹤0.01%	2767
2025 Q3	$426K	Buy	+26,266	New	+$373K	﹤0.01%	3061
2025 Q2	–	Sell	-34,999	Closed	-$770K	–	3272
2025 Q1	$770K	Sell	34,999 -96,668	-73%	-$2.54M	﹤0.01%	2319
2024 Q4	$3.52M	Sell	131,667 -129,791	-50%	-$4.13M	0.01%	1333
2024 Q3	$6.98M	Sell	261,458 -101,118	-28%	-$2.01M	0.02%	914
2024 Q2	$6.53M	Sell	362,576 -30,159	-8%	-$526K	0.01%	889
2024 Q1	$7.16M	Buy	392,735 +223,193	+132%	+$3.55M	0.02%	791
2023 Q4	$1.85M	Buy	169,542 +111,978	+195%	+$786K	﹤0.01%	1633
2023 Q3	$330K	Buy	+57,564	New	+$391K	﹤0.01%	2455

Other funds holding EWTX

OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Jupiter Topco New York $245B AUM

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

NHAS

Novo Holdings A/S Hellerup, Denmark $1.72B AUM 106.92% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Two Sigma Investments's EWTX Position: Q2 2026 in Review

Two Sigma Investments reduced its Edgewise Therapeutics (EWTX) stake by 2.6% in Q2 2026, selling an estimated $44.8K and leaving 49,548 shares worth $2.01M. The position accounts for ﹤0.01% of the portfolio, ranked #2994.

Two Sigma Investments first reported a position in EWTX in Q3 2023 and has held it in 11 quarters since. The position peaked at $7.16M in Q1 2024. 223 funds tracked by Wall St. Rank hold EWTX as of Q2 2026.

Two Sigma Investments held 49,548 shares of Edgewise Therapeutics worth $2.01M as of Q2 2026.
Two Sigma Investments sold 1,300 Edgewise Therapeutics shares in Q2 2026, an estimated $44.8K.
Edgewise Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q2 2026, its #2994 holding.
Two Sigma Investments first reported a position in Edgewise Therapeutics in Q3 2023 and has held it in 11 quarters since.
Two Sigma Investments's Edgewise Therapeutics position peaked at $7.16M in Q1 2024.
223 funds tracked by Wall St. Rank held Edgewise Therapeutics as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.