Two Sigma Investments

Two Sigma Investments’s Annexon ANNX Stock Holding History

Two Sigma Investments’s Portfolio ANNX Stock Details ANNX Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$2.61M	Buy	471,391 +139,353	+42%	+$784K	﹤0.01%	2564
2025 Q4	$1.67M	Buy	332,038 +52,904	+19%	+$202K	﹤0.01%	2572
2025 Q3	$851K	Buy	279,134 +77,974	+39%	+$194K	﹤0.01%	2685
2025 Q2	$483K	Buy	+201,160	New	+$403K	﹤0.01%	2602
2025 Q1	–	Sell	-137,183	Closed	-$704K	–	3185
2024 Q4	$704K	Sell	137,183 -3,734	-3%	-$23K	﹤0.01%	2370
2024 Q3	$834K	Sell	140,917 -185,487	-57%	-$1.1M	﹤0.01%	2227
2024 Q2	$1.6M	Sell	326,404 -47,044	-13%	-$243K	﹤0.01%	1701
2024 Q1	$2.68M	Buy	373,448 +346,865	+1,305%	+$1.8M	0.01%	1293
2023 Q4	$121K	Sell	26,583 -10,517	-28%	-$26K	﹤0.01%	2925
2023 Q3	$87.6K	Sell	37,100 -201,201	-84%	-$609K	﹤0.01%	2758
2023 Q2	$839K	Buy	238,301 +141,377	+146%	+$618K	﹤0.01%	2046
2023 Q1	$373K	Buy	+96,924	New	+$533K	﹤0.01%	2324
2022 Q3	–	Sell	-86,769	Closed	-$327K	–	2458
2022 Q2	$327K	Sell	86,769 -216,850	-71%	-$663K	﹤0.01%	1997
2022 Q1	$829K	Buy	303,619 +248,061	+446%	+$1.53M	﹤0.01%	1796
2021 Q4	$638K	Buy	+55,558	New	+$898K	﹤0.01%	3006

Other funds holding ANNX

Redmile Group San Francisco, California $1.51B AUM 164.17% 1-Year Est. Return

BlackRock New York $5.7T AUM 30.48% 1-Year Est. Return

Fidelity Investments

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Bain Capital Life Sciences Investors Boston, Massachusetts $1.11B AUM 171.34% 1-Year Est. Return

Bellevue Group Kuesnacht, Switzerland $4.2B AUM 54.85% 1-Year Est. Return

MAK Capital One New York $604M AUM 29.02% 1-Year Est. Return

Adage Capital Partners

Adage Capital Partners Boston, Massachusetts $64.8B AUM 42.7% 1-Year Est. Return