Two Sigma Advisers
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Two Sigma Advisers’s Arrowhead Research ARWR Stock Holding History

Two Sigma Advisers’s Portfolio ARWR Stock Details ARWR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-6,200
Closed -$412K – 172
2025
Q4 		$412K Sell
6,200
-15,534
-71% -$761K ﹤0.01% 1862
2025
Q3 		$750K Sell
21,734
-370,066
-94% -$8.14M ﹤0.01% 1601
2025
Q2 		$6.19M Sell
391,800
-332,000
-46% -$4.76M 0.01% 670
2025
Q1 		$9.22M Buy
723,800
+293,100
+68% +$5.33M 0.02% 559
2024
Q4 		$8.1M Buy
430,700
+330,700
+331% +$6.81M 0.02% 545
2024
Q3 		$1.94M Sell
100,000
-2,100
-2% -$51.3K ﹤0.01% 1082
2024
Q2 		$2.65M Buy
102,100
+63,300
+163% +$1.56M 0.01% 1041
2024
Q1 		$1.11M Sell
38,800
-38,700
-50% -$1.24M ﹤0.01% 1541
2023
Q4 		$2.37M Sell
77,500
-65,400
-46% -$1.74M 0.01% 1195
2023
Q3 		$3.84M Buy
142,900
+91,000
+175% +$2.79M 0.01% 868
2023
Q2 		$1.85M Buy
51,900
+19,900
+62% +$686K ﹤0.01% 1245
2023
Q1 		$813K Buy
+32,000
New +$1.01M ﹤0.01% 1734
2021
Q4 		– Sell
-20,300
Closed -$1.27M – 2616
2021
Q3 		$1.27M Sell
20,300
-33,500
-62% -$2.17M ﹤0.01% 1502
2021
Q2 		$4.46M Sell
53,800
-46,000
-46% -$3.42M 0.01% 918
2021
Q1 		$6.62M Buy
99,800
+45,600
+84% +$3.54M 0.02% 741
2020
Q4 		$4.16M Sell
54,200
-141,100
-72% -$9.02M 0.01% 903
2020
Q3 		$8.41M Sell
195,300
-467,800
-71% -$20.2M 0.02% 594
2020
Q2 		$28.6M Buy
663,100
+37,600
+6% +$1.33M 0.08% 252
2020
Q1 		$18M Buy
625,500
+471,300
+306% +$19M 0.07% 311
2019
Q4 		$9.78M Buy
154,200
+50,200
+48% +$2.49M 0.02% 605
2019
Q3 		$2.93M Sell
104,000
-138,400
-57% -$4.1M 0.01% 969
2019
Q2 		$6.42M Buy
242,400
+167,700
+224% +$3.68M 0.02% 731
2019
Q1 		$1.37M Buy
+74,700
New +$1.23M ﹤0.01% 1375
2018
Q4 		– Sell
-20,000
Closed -$383K – 2344
2018
Q3 		$383K Buy
+20,000
New +$328K ﹤0.01% 1891

Other funds holding ARWR

BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
Vanguard Portfolio Management
Vanguard Portfolio Management Malvern, Pennsylvania $2.22T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.88T AUM 44.46% 1-Year Est. Return
FAM
Fred Alger Management New York $30B AUM 76.99% 1-Year Est. Return
Invesco
Invesco Atlanta, Georgia $1.26T AUM 61.52% 1-Year Est. Return
VPC
Vestal Point Capital New York $4.28B AUM 239% 1-Year Est. Return

Two Sigma Advisers's ARWR Position: Q1 2026 in Review

Two Sigma Advisers sold out of Arrowhead Research (ARWR) in Q1 2026, closing a stake of 6,200 shares — an estimated $412K sold.

Two Sigma Advisers first reported a position in ARWR in Q3 2018 and held it in 24 quarters. The position peaked at $28.6M in Q2 2020. 438 funds tracked by Wall St. Rank hold ARWR as of Q1 2026.

  • Two Sigma Advisers reported no remaining Arrowhead Research position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 6,200 Arrowhead Research shares in Q1 2026, an estimated $412K.
  • Two Sigma Advisers first reported a position in Arrowhead Research in Q3 2018 and held it in 24 quarters.
  • Two Sigma Advisers's Arrowhead Research position peaked at $28.6M in Q2 2020.
  • 438 funds tracked by Wall St. Rank held Arrowhead Research as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.