State Street’s Spruce Biosciences SPRB Stock Holding History

State Street’s Portfolio SPRB Stock Details SPRB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q3	$2.87M	Buy	59,032 +8,582	+17%	+$435K	﹤0.01%	3294
2026 Q2	$2.72M	Buy	50,450 +45,050	+834%	+$2.52M	﹤0.01%	3283
2026 Q1	$353K	Sell	5,400 -1,000	-16%	-$69K	﹤0.01%	3739
2025 Q4	$558K	Buy	+6,400	New	+$686K	﹤0.01%	3650
2025 Q2	–	Sell	-809	Closed	-$17.6K	–	4338
2025 Q1	$17.6K	Hold	809	–	–	﹤0.01%	4222
2024 Q4	$25.5K	Sell	809 -50	-6%	-$1.83K	﹤0.01%	4208
2024 Q3	$30.6K	Hold	859	–	–	﹤0.01%	4170
2024 Q2	$33.3K	Hold	859	–	–	﹤0.01%	4213
2024 Q1	$50.6K	Buy	859 +32	+4%	+$8.14K	﹤0.01%	4156
2023 Q4	$182K	Hold	827	–	–	﹤0.01%	3925
2023 Q3	$140K	Buy	827 +43	+5%	+$7.25K	﹤0.01%	4027
2023 Q2	$126K	Sell	784 -457	-37%	-$76.4K	﹤0.01%	4154
2023 Q1	$206K	Hold	1,241	–	–	﹤0.01%	4070
2022 Q4	$102K	Hold	1,241	–	–	﹤0.01%	4364
2022 Q3	$128K	Hold	1,241	–	–	﹤0.01%	4354
2022 Q2	$162K	Sell	1,241 -1,498	-55%	-$192K	﹤0.01%	4302
2022 Q1	$413K	Buy	2,739 +1,046	+62%	+$195K	﹤0.01%	4127
2021 Q4	$566K	Sell	1,693 -11	-0.6%	-$3.27K	﹤0.01%	3973
2021 Q3	$768K	Buy	1,704 +38	+2%	+$23.9K	﹤0.01%	3844
2021 Q2	$1.4M	Buy	1,666 +403	+32%	+$430K	﹤0.01%	3606
2021 Q1	$1.57M	Buy	1,263 +90	+8%	+$138K	﹤0.01%	3521
2020 Q4	$2.14M	Buy	+1,173	New	+$1.94M	﹤0.01%	3343

Other funds holding SPRB

ACM

AIGH Capital Management Baltimore, Maryland $992M AUM 516.32% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.76T AUM

Geode Capital Management Boston, Massachusetts $1.92T AUM 36.1% 1-Year Est. Return

Carlyle Group Washington, District of Columbia $8.36B AUM 14.46% 1-Year Est. Return

Quinn Opportunity Partners Charlottesville, Virginia $1.85B AUM 1.27% 1-Year Est. Return

DMKJ

David M. Knott Jr $183M AUM 73.23% 1-Year Est. Return

Vanguard Fiduciary Trust Malvern, Pennsylvania $463B AUM

Vanguard Portfolio Management Malvern, Pennsylvania $2.21T AUM

Persistent Asset Partners Hong Kong $362M AUM 191.92% 1-Year Est. Return

Dimensional Fund Advisors Austin, Texas $551B AUM 33.95% 1-Year Est. Return

State Street's SPRB Position: Q3 2026 in Review

State Street increased its Spruce Biosciences (SPRB) stake by 17% in Q3 2026, buying an estimated $435K and bringing the position to 59,032 shares worth $2.87M. The position accounts for ﹤0.01% of the portfolio, ranked #3294.

State Street first reported a position in SPRB in Q4 2020 and has held it in 22 quarters since. 40 funds tracked by Wall St. Rank hold SPRB as of Q3 2026.

State Street held 59,032 shares of Spruce Biosciences worth $2.87M as of Q3 2026.
State Street bought 8,582 Spruce Biosciences shares in Q3 2026, an estimated $435K.
Spruce Biosciences made up ﹤0.01% of State Street's portfolio in Q3 2026, its #3294 holding.
State Street first reported a position in Spruce Biosciences in Q4 2020 and has held it in 22 quarters since.
40 funds tracked by Wall St. Rank held Spruce Biosciences as of Q3 2026.

Based on State Street's 13F filing for Q3 2026, filed 12 Nov 2026.