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Siren LLC Portfolio holdings
AUM
$3.61B
1-Year Est. Return
203.3%
This Fund
S&P 500
This Quarter
Est. Return
+36.54%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.35B
AUM Growth
+$796M
(+31%)
Cap. Flow
+$176M
Cap. Flow
% of AUM
5.24%
Top 10 Holdings %
Top 10 Hldgs %
46.31%
Holding
141
New
26
Increased
29
Reduced
24
Closed
28
Top Buys
| Rank | Stock | Value |
|---|---|---|
| 1 |
Scholar Rock
SRRK
|
+$59.1M |
| 2 |
Olema Pharmaceuticals
OLMA
|
+$58.7M |
| 3 |
Zymeworks
ZYME
|
+$36.6M |
| 4 |
DBVT
DBV Technologies
DBVT
|
+$29M |
| 5 |
Mineralys Therapeutics
MLYS
|
+$28.1M |
Top Sells
| Rank | Stock | Value |
|---|---|---|
| 1 |
Arrowhead Research
ARWR
|
+$57.3M |
| 2 |
RNAM
Avidity Biosciences
RNAM
|
+$56M |
| 3 |
Rezolute
RZLT
|
+$45.8M |
| 4 |
SLNO
Soleno Therapeutics
SLNO
|
+$31.6M |
| 5 |
Dyne Therapeutics
DYN
|
+$23.2M |
Sector Composition
| Rank | Sector | Weight |
|---|---|---|
| 1 | Healthcare | 93.02% |
| 2 | Technology | 3.72% |
| 3 | Communication Services | 1.9% |
| 4 | Real Estate | 0.59% |
| 5 | Consumer Discretionary | 0.59% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Change in Stake | Capital Flow | |
|---|---|---|---|---|---|---|
126
ProQR Therapeutics
PRQR
$244M
| – | – |
-1,552,183
| Closed | -$3.31M |
|
127
uniQure
QURE
$2.63B
| – | – |
-275,200
| Closed | -$16.1M |
|
|
RNAM
128
DELISTED
Avidity Biosciences
RNAM
| – | – |
-1,285,610
| Closed | -$56M |
|
129
Cartesian Therapeutics
RNAC
$229M
| – | – |
-563,272
| Closed | -$5.76M |
|
|
130
Rezolute
RZLT
$476M
| – | – |
-4,870,000
| Closed | -$45.8M |
|
|
SEMR
131
DELISTED
Semrush
SEMR
| – | – |
-125,000
| Closed | -$885K |
|
|
SLNO
132
DELISTED
Soleno Therapeutics
SLNO
| – | – |
-467,342
| Closed | -$31.6M |
|
133
Spotify
SPOT
$102B
| – | – |
-2,173
| Closed | -$1.52M |
|
134
Vertiv
VRT
$110B
| – | – |
-2,000
| Closed | -$302K |
|
135
ArriVent BioPharma
AVBP
$1.4B
| – | – |
-700,000
| Closed | -$12.9M |
|
136
Amer Sports
AS
$20.5B
| – | – |
-25,000
| Closed | -$869K |
|
137
Astera Labs
ALAB
$48.4B
| – | – |
-3,500
| Closed | -$685K |
|
|
BIOA
138
BioAge Labs
BIOA
$928M
| – | – |
-382,406
| Closed | -$2.25M |
|
|
SAIL
139
SailPoint Inc
SAIL
$8.7B
| – | – |
-50,000
| Closed | -$1.1M |
|
|
CHYM
140
Chime Financial
CHYM
$8.33B
| – | – |
-25,000
| Closed | -$504K |
|
|
NIQ
141
NIQ Global Intelligence PLC
NIQ
$3.27B
| – | – |
-95,000
| Closed | -$1.49M |
|
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Siren LLC's Q4 2025 Portfolio in Review
As of Q4 2025, Siren LLC held 141 positions worth $3.35B, up 31% from $2.56B the previous quarter. Its ten largest holdings account for 46% of the portfolio.
Siren LLC deployed $176M of net new capital in Q4 2025, opening 26 new positions and adding to 29 existing holdings. Its largest new stake was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
By sector, the portfolio is most concentrated in Healthcare at 93% of assets, up from 91% a quarter earlier, followed by Technology and Communication Services.
On the sell side, the largest reduction was Arrowhead Research, an estimated $57.3M trimmed.
- Siren LLC's largest Q4 2025 buy was Olema Pharmaceuticals: 3,300,700 shares worth $82.5M.
- Siren LLC added most to Scholar Rock in Q4 2025, an estimated $59.1M increase.
- Siren LLC's biggest Q4 2025 reduction was Arrowhead Research, cutting an estimated $57.3M.
- Siren LLC fully exited Avidity Biosciences in Q4 2025, selling an estimated $56M.
- Siren LLC's ten largest holdings make up 46% of its $3.35B portfolio in Q4 2025.
- Siren LLC opened 26 new positions and closed 28 in Q4 2025.
- Siren LLC's portfolio value rose 31% quarter-over-quarter to $3.35B.
Based on Siren LLC's 13F filing for Q4 2025, filed 13 Feb 2026.