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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+18.65%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.93B
AUM Growth
+$160M
Cap. Flow
+$578K
Cap. Flow %
0.03%
Top 10 Hldgs %
48.49%
Holding
131
New
15
Increased
21
Reduced
19
Closed
21

Top Buys

Rank Stock Value
1
DYN icon
Dyne Therapeutics
DYN
+$23.3M
2
BCAX
Bicara Therapeutics
BCAX
+$23.2M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$21.1M
4
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$20.7M
5
AVBP icon
ArriVent BioPharma
AVBP
+$14.5M

Top Sells

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$64.3M
2
SLNO
Soleno Therapeutics
SLNO
+$19.5M
3
PRTA icon
Prothena Corp
PRTA
+$15.9M
4
SMMT icon
Summit Therapeutics
SMMT
+$13.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$13.1M

Sector Composition

Rank Sector Weight
1 Healthcare 90.42%
2 Technology 4.93%
3 Communication Services 2.51%
4 Consumer Discretionary 1.07%
5 Real Estate 0.77%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
TEAM icon
101
Atlassian
TEAM
$37.8B
$711K 0.04%
+3,500
New +$729K
PCOR icon
102
Procore
PCOR
$8.67B
$684K 0.04%
10,000
– –
CCC
103
CCC Intelligent Solutions
CCC
$4.08B
$471K 0.02%
+50,000
New +$447K
PCG icon
104
PG&E
PCG
$38.5B
$349K 0.02%
+25,000
New +$407K
CYCN icon
105
Cyclerion Therapeutics
CYCN
$16.7M
$338K 0.02%
116,155
– –
RDDT icon
106
Reddit
RDDT
$31.1B
$301K 0.02%
2,000
-21,500
-91% -$2.44M
VRT icon
107
Vertiv
VRT
$105B
$257K 0.01%
+2,000
New +$194K
DECK icon
108
Deckers Outdoor
DECK
$13.3B
$206K 0.01%
2,000
-3,000
-60% -$332K
CRBU icon
109
Caribou Biosciences
CRBU
$164M
$133K 0.01%
105,347
– –
IRWD icon
110
Ironwood Pharmaceuticals
IRWD
$711M
$79.6K ﹤0.01%
110,532
– –
BA icon
111
Boeing
BA
$185B
– –
-5,000
Closed -$853K
BASE
112
DELISTED
Couchbase
BASE
– –
-49,850
Closed -$785K
BILL icon
113
BILL Holdings
BILL
$4.78B
– –
-28,500
Closed -$1.31M
BPMC
114
DELISTED
Blueprint Medicines
BPMC
– –
-726,167
Closed -$64.3M
GDS icon
115
GDS Holdings
GDS
$6.41B
– –
-12,500
Closed -$317K
INFA
116
DELISTED
Informatica
INFA
– –
-50,000
Closed -$873K
INTC icon
117
Intel
INTC
$513B
– –
-40,000
Closed -$908K
KRON
118
DELISTED
Kronos Bio
KRON
– –
-842,954
Closed -$695K
LPLA icon
119
LPL Financial
LPLA
$28.6B
– –
-7,500
Closed -$2.45M
MDB icon
120
MongoDB
MDB
$32.1B
– –
-5,500
Closed -$965K
MRVL icon
121
Marvell Technology
MRVL
$196B
– –
-36,808
Closed -$2.27M
NKE icon
122
Nike
NKE
$61.9B
– –
-15,000
Closed -$952K
OXY icon
123
Occidental Petroleum
OXY
$55.9B
– –
-10,000
Closed -$494K
PEGA icon
124
Pegasystems
PEGA
$5.38B
– –
-33,000
Closed -$1.15M
PRTA icon
125
Prothena Corp
PRTA
$459M
– –
-1,283,555
Closed -$15.9M
2 3 4
5
6

Similar funds

SCM
Saba Capital Management New York $3.62B AUM 12.96% 1-Year Est. Return
ACM
Advent Capital Management New York $3.63B AUM 0.29% 1-Year Est. Return
GCM
Ghisallo Capital Management Boston, Massachusetts $3.63B AUM 30.51% 1-Year Est. Return
VI
Vestcor Inc Fredericton, New Brunswick, Canada $3.63B AUM 21.49% 1-Year Est. Return
BPS
BNDES Participacoes SA Rio De Janeiro, Brazil $3.58B AUM
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q2 2025 Portfolio in Review

As of Q2 2025, Siren LLC held 131 positions worth $1.93B, up 9% from $1.77B the previous quarter. Its ten largest holdings account for 48% of the portfolio.

Siren LLC's Q2 2025 filing shows 15 new, 21 increased, 19 reduced and 21 closed positions. Its largest new stake was MoonLake Immunotherapeutics: 508,267 shares worth $24M. The largest sale was Blueprint Medicines, an estimated $64.3M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q2 2025 buy was MoonLake Immunotherapeutics: 508,267 shares worth $24M.
  • Siren LLC added most to Dyne Therapeutics in Q2 2025, an estimated $23.3M increase.
  • Siren LLC's biggest Q2 2025 reduction was Soleno Therapeutics, cutting an estimated $19.5M.
  • Siren LLC fully exited Blueprint Medicines in Q2 2025, selling an estimated $64.3M.
  • Siren LLC's ten largest holdings make up 48% of its $1.93B portfolio in Q2 2025.
  • Siren LLC opened 15 new positions and closed 21 in Q2 2025.
  • Siren LLC's portfolio value rose 9% quarter-over-quarter to $1.93B.

Based on Siren LLC's 13F filing for Q2 2025, filed 13 Aug 2025.