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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
-13.7%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$1.77B
AUM Growth
-$491M
Cap. Flow
+$34.8M
Cap. Flow %
1.96%
Top 10 Hldgs %
50.37%
Holding
141
New
23
Increased
28
Reduced
41
Closed
25

Top Buys

Rank Stock Value
1
BPMC
Blueprint Medicines
BPMC
+$70.8M
2
IRON icon
Disc Medicine
IRON
+$59.6M
3
EWTX icon
Edgewise Therapeutics
EWTX
+$25.2M
4
DYN icon
Dyne Therapeutics
DYN
+$19.6M
5
SLNO
Soleno Therapeutics
SLNO
+$18.3M

Top Sells

Rank Stock Value
1
ARGX icon
argenx
ARGX
+$70.8M
2
SWTX
SpringWorks Therapeutics
SWTX
+$49.8M
3
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$38.9M
4
ONC
BeOne Medicines Ltd
ONC
+$36.2M
5
CYTK icon
Cytokinetics
CYTK
+$18.9M

Sector Composition

Rank Sector Weight
1 Healthcare 89.75%
2 Technology 5.2%
3 Communication Services 2.41%
4 Consumer Discretionary 1.21%
5 Real Estate 0.81%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
INTC icon
101
Intel
INTC
$513B
$908K 0.05%
40,000
– –
INFA
102
DELISTED
Informatica
INFA
$873K 0.05%
+50,000
New +$1.1M
BA icon
103
Boeing
BA
$185B
$853K 0.05%
5,000
-20,000
-80% -$3.46M
BASE
104
DELISTED
Couchbase
BASE
$785K 0.04%
49,850
-10,150
-17% -$168K
AGEN
105
Agenus
AGEN
$290M
$753K 0.04%
+500,000
New +$1.44M
KRON
106
DELISTED
Kronos Bio
KRON
$695K 0.04%
842,954
– –
PCOR icon
107
Procore
PCOR
$8.67B
$660K 0.04%
10,000
-10,000
-50% -$755K
RACE icon
108
Ferrari
RACE
$72.5B
$636K 0.04%
1,500
-500
-25% -$225K
HOOK
109
DELISTED
HOOKIPA Pharma
HOOK
$612K 0.03%
566,640
– –
DECK icon
110
Deckers Outdoor
DECK
$13.3B
$559K 0.03%
+5,000
New +$808K
USB icon
111
US Bancorp
USB
$99.6B
$528K 0.03%
+12,500
New +$577K
OXY icon
112
Occidental Petroleum
OXY
$55.9B
$494K 0.03%
10,000
-5,000
-33% -$244K
GDS icon
113
GDS Holdings
GDS
$6.41B
$317K 0.02%
+12,500
New +$379K
CYCN icon
114
Cyclerion Therapeutics
CYCN
$16.7M
$290K 0.02%
116,155
– –
IRWD icon
115
Ironwood Pharmaceuticals
IRWD
$714M
$162K 0.01%
110,532
– –
CRBU icon
116
Caribou Biosciences
CRBU
$164M
$96.2K 0.01%
105,347
– –
APLT
117
DELISTED
Applied Therapeutics
APLT
– –
-1,633,768
Closed -$1.4M
ARGX icon
118
argenx
ARGX
$54.1B
– –
-115,045
Closed -$70.8M
BZ icon
119
Kanzhun
BZ
$7.36B
– –
-25,000
Closed -$345K
CYTK icon
120
Cytokinetics
CYTK
$10.4B
– –
-402,323
Closed -$18.9M
DLTR icon
121
Dollar Tree
DLTR
$25.2B
– –
-10,000
Closed -$749K
ESTC icon
122
Elastic
ESTC
$7.81B
– –
-25,000
Closed -$2.48M
FCX icon
123
Freeport-McMoran
FCX
$97.5B
– –
-75,000
Closed -$2.86M
GOSS icon
124
CALL
Gossamer Bio
GOSS
$87M
– –
-207,000
Closed -$187K
HCA icon
125
HCA Healthcare
HCA
$89.5B
– –
-3,750
Closed -$1.13M
2 3 4
5
6

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GCM
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VI
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BPS
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VPC
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WWA
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OCM
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Siren LLC's Q1 2025 Portfolio in Review

As of Q1 2025, Siren LLC held 141 positions worth $1.77B, down 22% from $2.26B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Siren LLC's Q1 2025 filing shows 23 new, 28 increased, 41 reduced and 25 closed positions. Its largest new stake was Blueprint Medicines: 726,167 shares worth $64.3M. The largest sale was argenx, an estimated $70.8M.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, down from 93% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q1 2025 buy was Blueprint Medicines: 726,167 shares worth $64.3M.
  • Siren LLC added most to Edgewise Therapeutics in Q1 2025, an estimated $25.2M increase.
  • Siren LLC's biggest Q1 2025 reduction was BeOne Medicines Ltd, cutting an estimated $36.2M.
  • Siren LLC fully exited argenx in Q1 2025, selling an estimated $70.8M.
  • Siren LLC's ten largest holdings make up 50% of its $1.77B portfolio in Q1 2025.
  • Siren LLC opened 23 new positions and closed 25 in Q1 2025.
  • Siren LLC's portfolio value fell 22% quarter-over-quarter to $1.77B.

Based on Siren LLC's 13F filing for Q1 2025, filed 14 May 2025.