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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+45.46%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
+$9.78M
Cap. Flow %
0.38%
Top 10 Hldgs %
47.45%
Holding
133
New
23
Increased
24
Reduced
15
Closed
18

Top Buys

Rank Stock Value
1
RZLT icon
Rezolute
RZLT
+$32.4M
2
GPCR icon
Structure Therapeutics
GPCR
+$20.5M
3
RELY icon
Remitly
RELY
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

Rank Stock Value
1
MRUS
Merus
MRUS
+$44.9M
2
APGE icon
Apogee Therapeutics
APGE
+$25.8M
3
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

Rank Sector Weight
1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
FHTX icon
76
Foghorn Therapeutics
FHTX
$360M
$3.52M 0.14%
720,720
– –
PRQR icon
77
ProQR Therapeutics
PRQR
$265M
$3.31M 0.13%
1,552,183
– –
EDU icon
78
New Oriental
EDU
$8.98B
$3.29M 0.13%
62,000
-10,000
-14% -$494K
CRWV
79
CoreWeave
CRWV
$49.5B
$3.28M 0.13%
+24,000
New +$2.84M
PEPG icon
80
PepGen
PEPG
$197M
$3.23M 0.13%
+700,000
New +$1.13M
GTLB icon
81
GitLab
GTLB
$6.58B
$2.89M 0.11%
64,000
+29,000
+83% +$1.33M
BEKE icon
82
KE Holdings
BEKE
$18.8B
$2.75M 0.11%
145,000
+40,000
+38% +$750K
PANW icon
83
Palo Alto Networks
PANW
$297B
$2.74M 0.11%
13,450
+1,950
+17% +$373K
TENX icon
84
Tenax Therapeutics
TENX
$503M
$2.68M 0.1%
+352,441
New +$2.15M
WK icon
85
Workiva
WK
$3.54B
$2.58M 0.1%
30,000
+2,000
+7% +$150K
QCOM icon
86
Qualcomm
QCOM
$176B
$2.33M 0.09%
14,000
– –
BIOA
87
BioAge Labs
BIOA
$538M
$2.25M 0.09%
382,406
– –
KDP icon
88
Keurig Dr Pepper
KDP
$40.8B
$1.97M 0.08%
+77,050
New +$2.41M
HUBS icon
89
HubSpot
HUBS
$10.5B
$1.87M 0.07%
4,000
+1,000
+33% +$503K
CMG icon
90
Chipotle Mexican Grill
CMG
$41.5B
$1.86M 0.07%
+47,500
New +$2.14M
KLRS
91
Kalaris Therapeutics
KLRS
$96.8M
$1.84M 0.07%
318,264
+35,678
+13% +$118K
GBIO
92
DELISTED
Generation Bio
GBIO
$1.82M 0.07%
296,892
-1
-0% -$5
CLBT icon
93
Cellebrite
CLBT
$3.99B
$1.67M 0.07%
90,000
+30,000
+50% +$471K
PRMB
94
Primo Brands
PRMB
$8.54B
$1.66M 0.06%
75,000
+37,500
+100% +$970K
SPOT icon
95
Spotify
SPOT
$100B
$1.52M 0.06%
+2,173
New +$1.52M
NIQ
96
NIQ Global Intelligence PLC
NIQ
$3.45B
$1.49M 0.06%
+95,000
New +$1.65M
MNDY icon
97
monday.com
MNDY
$3.94B
$1.36M 0.05%
+7,000
New +$1.61M
SAIL
98
SailPoint Inc
SAIL
$10.6B
$1.1M 0.04%
50,000
– –
ESTC icon
99
Elastic
ESTC
$7.81B
$1.06M 0.04%
+12,500
New +$1.05M
IREN icon
100
Iris Energy
IREN
$14.7B
$938K 0.04%
+20,000
New +$486K
2 3
4
5 6

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ACM
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GCM
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VI
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BPS
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VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
WWA
WCG Wealth Advisors Las Vegas, Nevada $3.57B AUM 18.63% 1-Year Est. Return
OCM
One Capital Management Westlake Village, California $3.65B AUM 15.32% 1-Year Est. Return

Siren LLC's Q3 2025 Portfolio in Review

As of Q3 2025, Siren LLC held 133 positions worth $2.56B, up 32% from $1.93B the previous quarter. Its ten largest holdings account for 47% of the portfolio.

Siren LLC's Q3 2025 filing shows 23 new, 24 increased, 15 reduced and 18 closed positions. Its largest new stake was Rezolute: 4,870,000 shares worth $45.8M. The largest sale was Merus, an estimated $44.9M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q3 2025 buy was Rezolute: 4,870,000 shares worth $45.8M.
  • Siren LLC added most to Remitly in Q3 2025, an estimated $19.8M increase.
  • Siren LLC's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $11.1M.
  • Siren LLC fully exited Merus in Q3 2025, selling an estimated $44.9M.
  • Siren LLC's ten largest holdings make up 47% of its $2.56B portfolio in Q3 2025.
  • Siren LLC opened 23 new positions and closed 18 in Q3 2025.
  • Siren LLC's portfolio value rose 32% quarter-over-quarter to $2.56B.

Based on Siren LLC's 13F filing for Q3 2025, filed 13 Nov 2025.