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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+45.46%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
+$9.78M
Cap. Flow %
0.38%
Top 10 Hldgs %
47.45%
Holding
133
New
23
Increased
24
Reduced
15
Closed
18

Top Buys

Rank Stock Value
1
RZLT icon
Rezolute
RZLT
+$32.4M
2
GPCR icon
Structure Therapeutics
GPCR
+$20.5M
3
RELY icon
Remitly
RELY
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

Rank Stock Value
1
MRUS
Merus
MRUS
+$44.9M
2
APGE icon
Apogee Therapeutics
APGE
+$25.8M
3
MLTX icon
MoonLake Immunotherapeutics
MLTX
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

Rank Sector Weight
1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SEER icon
51
Seer Inc
SEER
$120M
$8.68M 0.34%
4,000,000
– –
NBIS
52
Nebius Group N.V.
NBIS
$47.7B
$8.15M 0.32%
72,600
+21,600
+42% +$1.5M
NMRA icon
53
Neumora Therapeutics
NMRA
$302M
$7.93M 0.31%
4,358,283
– –
TSM icon
54
TSMC
TSM
$2.18T
$7.88M 0.31%
28,200
-2,300
-8% -$562K
CRM icon
55
Salesforce
CRM
$158B
$7.13M 0.28%
30,100
+7,500
+33% +$1.89M
CGEM icon
56
Cullinan Oncology
CGEM
$1.14B
$7.08M 0.28%
1,193,410
– –
NVDA icon
57
NVIDIA
NVDA
$5.42T
$6.99M 0.27%
37,485
-12,500
-25% -$2.18M
NOW icon
58
ServiceNow
NOW
$129B
$6.56M 0.26%
35,630
+10,000
+39% +$1.87M
SYRE icon
59
Spyre Therapeutics
SYRE
$9.25B
$6.18M 0.24%
368,598
– –
RNAC icon
60
Cartesian Therapeutics
RNAC
$268M
$5.76M 0.23%
563,272
– –
PDD icon
61
Pinduoduo
PDD
$131B
$5.74M 0.22%
43,401
-9,500
-18% -$1.12M
ELDN icon
62
Eledon Pharmaceuticals
ELDN
$285M
$5.37M 0.21%
2,072,767
+1,382,597
+200% +$4.04M
ADBE icon
63
Adobe
ADBE
$105B
$5.31M 0.21%
15,051
– –
GOOGL icon
64
Alphabet (Google) Class A
GOOGL
$4.33T
$5.15M 0.2%
21,203
-29,500
-58% -$6.18M
FROG icon
65
JFrog
FROG
$10.8B
$5.07M 0.2%
107,116
– –
SGMT icon
66
Sagimet Biosciences
SGMT
$559M
$4.97M 0.19%
724,771
– –
DT icon
67
Dynatrace
DT
$14.2B
$4.86M 0.19%
100,229
+25,000
+33% +$1.27M
DDOG icon
68
Datadog
DDOG
$84B
$4.69M 0.18%
32,925
-5,500
-14% -$757K
NBP
69
NovaBridge Biosciences American Depositary Shares
NBP
$202M
$4.41M 0.17%
+1,165,957
New +$3.96M
AGEN
70
Agenus
AGEN
$290M
$4.1M 0.16%
1,064,250
– –
LXEO icon
71
Lexeo Therapeutics
LXEO
$378M
$4.01M 0.16%
603,435
– –
BDTX icon
72
Black Diamond Therapeutics
BDTX
$112M
$3.97M 0.16%
1,046,517
– –
WHWK
73
Whitehawk Therapeutics
WHWK
$271M
$3.96M 0.15%
2,082,000
– –
VTVT icon
74
vTv Therapeutics
VTVT
$139M
$3.81M 0.15%
+163,000
New +$2.86M
TIL icon
75
Instil Bio
TIL
$50.3M
$3.64M 0.14%
203,933
– –
1 2
3
4 5

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ACM
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GCM
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VI
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BPS
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VPC
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WWA
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OCM
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Siren LLC's Q3 2025 Portfolio in Review

As of Q3 2025, Siren LLC held 133 positions worth $2.56B, up 32% from $1.93B the previous quarter. Its ten largest holdings account for 47% of the portfolio.

Siren LLC's Q3 2025 filing shows 23 new, 24 increased, 15 reduced and 18 closed positions. Its largest new stake was Rezolute: 4,870,000 shares worth $45.8M. The largest sale was Merus, an estimated $44.9M.

By sector, the portfolio is most concentrated in Healthcare at 91% of assets, up from 90% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q3 2025 buy was Rezolute: 4,870,000 shares worth $45.8M.
  • Siren LLC added most to Remitly in Q3 2025, an estimated $19.8M increase.
  • Siren LLC's biggest Q3 2025 reduction was Disc Medicine, cutting an estimated $11.1M.
  • Siren LLC fully exited Merus in Q3 2025, selling an estimated $44.9M.
  • Siren LLC's ten largest holdings make up 47% of its $2.56B portfolio in Q3 2025.
  • Siren LLC opened 23 new positions and closed 18 in Q3 2025.
  • Siren LLC's portfolio value rose 32% quarter-over-quarter to $2.56B.

Based on Siren LLC's 13F filing for Q3 2025, filed 13 Nov 2025.