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OrbiMed Portfolio holdings

AUM $5.4B
1-Year Est. Return 163.13%
This Fund
S&P 500
This Quarter Est. Return
+12.84%
1 Year Est. Return
+163.13%
3 Year Est. Return
+393.16%
5 Year Est. Return
+486.34%
10 Year Est. Return
+3,312.73%
AUM
$5.05B
AUM Growth
+$146M
Cap. Flow
-$430M
Cap. Flow %
-8.52%
Top 10 Hldgs %
43.4%
Holding
134
New
26
Increased
24
Reduced
35
Closed
22
Avg Time Held Equity + Options
7.7 quarters
Top 10 Avg Time Held Equity + Options
5.6 quarters
Top 20 Avg Time Held Equity + Options
7.5 quarters
Avg Time Held Equity only
8 quarters
Top 10 Avg Time Held Equity only
5.7 quarters
Top 20 Avg Time Held Equity only
7.9 quarters

Top Buys

Rank Stock Value
1
AZN icon
AstraZeneca
AZN
+$129M
2
MRK icon
Merck
MRK
+$76.6M
3
GH icon
Guardant Health
GH
+$43.7M
4
MLYS icon
Mineralys Therapeutics
MLYS
+$31.5M
5
QURE icon
uniQure
QURE
+$28.3M

Top Sells

Rank Stock Value
1
TERN icon
Terns Pharmaceuticals
TERN
+$87M
2
LLY icon
Eli Lilly
LLY
+$65.3M
3
APLS icon
Apellis Pharmaceuticals
APLS
+$61M
4
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$57.8M
5
CI icon
Cigna
CI
+$56.4M

Sector Composition

Rank Sector Weight
1 Healthcare 90.42%
2 Miscellaneous 9.58%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow Held Since
MLYS icon
26
Mineralys Therapeutics
MLYS
$1.83B
$55.6M 1.1%
2,052,900
+1,072,500
+109% +$31.5M
2025 Q2
3 quarters
PRAX icon
27
Praxis Precision Medicines
PRAX
$6.82B
$55.6M 1.1%
172,500
+78,000
+83% +$24.1M
2025 Q4
1 quarter
PFE icon
28
Pfizer
PFE
$161B
$54.7M 1.08%
1,946,500
+293,600
+18% +$7.82M
2025 Q4
1 quarter
DYN icon
29
Dyne Therapeutics
DYN
$2.91B
$52.9M 1.05%
2,917,884
+715,700
+32% +$12.3M
2024 Q1
8 quarters
NTRA icon
30
Natera
NTRA
$57.1B
$52.4M 1.04%
262,000
-103,800
-28% -$22.3M
2015 Q3
42 quarters
ABVX icon
31
Abivax
ABVX
$7.41B
$51.9M 1.03%
465,700
+97,800
+27% +$11.6M
2025 Q3
2 quarters
UPB icon
32
Upstream Bio Inc
UPB
$203M
$51.2M 1.02%
5,693,589
– –
2024 Q4
5 quarters
DHR icon
33
Danaher
DHR
$159B
$50.4M 1%
265,800
-34,000
-11% -$7.24M
2025 Q3
2 quarters
CAI icon
34
Caris Life Sciences
CAI
$8.4B
$50.2M 0.99%
2,806,811
-309,200
-10% -$6.76M
2025 Q2
3 quarters
RCEL icon
35
Avita Medical
RCEL
$413M
$42.5M 0.84%
+544,895
New +$2.29M
2026 Q1
0 quarters
ASND icon
36
Ascendis Pharma A/S
ASND
$14.7B
$41.6M 0.83%
181,977
+10,000
+6% +$2.24M
2025 Q2
3 quarters
STTK icon
37
Shattuck Labs
STTK
$566M
$40.5M 0.8%
6,306,127
– –
2025 Q3
2 quarters
GH icon
38
Guardant Health
GH
$22.1B
$40.2M 0.8%
+435,200
New +$43.7M
2026 Q1
0 quarters
ALNY icon
39
Alnylam Pharmaceuticals
ALNY
$29.9B
$39.4M 0.78%
119,000
-169,800
-59% -$57.8M
2024 Q2
7 quarters
PRLD icon
40
Prelude Therapeutics
PRLD
$283M
$37.3M 0.74%
10,909,256
– –
2020 Q3
22 quarters
CRNX icon
41
DELISTED
Crinetics Pharmaceuticals
CRNX
$36.3M 0.72%
999,000
– –
2018 Q3
30 quarters
AXSM icon
42
Axsome Therapeutics
AXSM
$8.21B
$36.2M 0.72%
213,921
-39,200
-15% -$6.77M
2025 Q1
4 quarters
QURE icon
43
uniQure
QURE
$1.47B
$34.9M 0.69%
2,136,149
+1,398,749
+190% +$28.3M
2025 Q3
2 quarters
ORIC icon
44
Oric Pharmaceuticals
ORIC
$1.2B
$34.1M 0.68%
2,693,929
-947,827
-26% -$10.8M
2025 Q1
4 quarters
ELV icon
45
Elevance Health
ELV
$92.7B
$33.6M 0.67%
114,700
+15,600
+16% +$5.13M
2025 Q4
1 quarter
RLMD icon
46
Relmada Therapeutics
RLMD
$367M
$32.8M 0.65%
4,715,864
+2,105,264
+81% +$9.96M
2025 Q4
1 quarter
FBRX icon
47
DELISTED
Forte Biosciences
FBRX
$31M 0.61%
1,196,955
– –
2024 Q4
5 quarters
TRVI icon
48
Trevi Therapeutics
TRVI
$1.78B
$29.3M 0.58%
2,454,400
-736,300
-23% -$8.24M
2025 Q1
4 quarters
ESPR icon
49
DELISTED
Esperion Therapeutics
ESPR
$29M 0.57%
10,570,300
+4,604,802
+77% +$14.6M
2025 Q4
1 quarter
NPCE icon
50
Neuropace
NPCE
$442M
$27.6M 0.55%
2,096,527
-309,808
-13% -$4.65M
2021 Q2
19 quarters
1
2
3 4 5

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OrbiMed's Q1 2026 Portfolio in Review

As of Q1 2026, OrbiMed held 134 positions worth $5.05B, up 3% from $4.9B the previous quarter. Its ten largest holdings account for 43% of the portfolio.

OrbiMed withdrew a net $430M in Q1 2026, closing 22 positions and reducing 35 holdings. Its most notable exit was Terns Pharmaceuticals, an estimated $87M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 90% of assets, down from 99% a quarter earlier, followed by Miscellaneous.

Against the trend, OrbiMed opened a new position in AstraZeneca worth $132M.

  • OrbiMed's largest Q1 2026 buy was AstraZeneca: 670,200 shares worth $132M.
  • OrbiMed added most to Mineralys Therapeutics in Q1 2026, an estimated $31.5M increase.
  • OrbiMed's biggest Q1 2026 reduction was Eli Lilly, cutting an estimated $65.3M.
  • OrbiMed fully exited Terns Pharmaceuticals in Q1 2026, selling an estimated $87M.
  • OrbiMed's ten largest holdings make up 43% of its $5.05B portfolio in Q1 2026.
  • OrbiMed opened 26 new positions and closed 22 in Q1 2026.
  • OrbiMed's portfolio value rose 3% quarter-over-quarter to $5.05B.

Based on OrbiMed's 13F filing for Q1 2026, filed 15 May 2026.