OM

Opaleye Management Portfolio holdings

AUM $707M
1-Year Est. Return 67.55%
This Quarter Est. Return
1 Year Est. Return
+67.55%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$707M
AUM Growth
+$213M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
52
New
Increased
Reduced
Closed

Top Buys

1
+$14.4M
2
+$13.5M
3
+$7.93M
4
DERM icon
Journey Medical
DERM
+$6.24M
5
SLGL icon
Sol-Gel Technologies
SLGL
+$5.97M

Top Sells

1
+$7.95M
2
+$6.23M
3
+$5.9M
4
DNA icon
Ginkgo Bioworks
DNA
+$5.63M
5
IMNM icon
Immunome
IMNM
+$4.04M

Sector Composition

1 Healthcare 99.35%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PLX icon
26
Protalix BioTherapeutics
PLX
$166M
$5.73M 0.81%
+2,580,556
TMCI icon
27
Treace Medical Concepts
TMCI
$172M
$4.71M 0.67%
+702,245
RVMD icon
28
Revolution Medicines
RVMD
$23.4B
$4.67M 0.66%
100,000
-5,000
MBX
29
MBX Biosciences
MBX
$1.93B
$4.43M 0.63%
253,000
+13,681
TRVI icon
30
Trevi Therapeutics
TRVI
$1.47B
$3.57M 0.5%
390,000
ADCT icon
31
ADC Therapeutics
ADCT
$460M
$2.73M 0.39%
+682,529
ALMS
32
Alumis Inc
ALMS
$3.03B
$2.65M 0.38%
665,000
-110,000
CABA icon
33
Cabaletta Bio
CABA
$207M
$1.89M 0.27%
+808,882
IRD
34
Opus Genetics
IRD
$150M
$1.81M 0.26%
1,100,000
-120,000
ZYME icon
35
Zymeworks
ZYME
$1.86B
$1.71M 0.24%
100,000
-110,000
SYRE icon
36
Spyre Therapeutics
SYRE
$2.57B
$1.09M 0.15%
+65,000
RIGL icon
37
Rigel Pharmaceuticals
RIGL
$710M
$1.07M 0.15%
+37,787
ACOG
38
Alpha Cognition
ACOG
$129M
$750K 0.11%
+115,142
ZNTL icon
39
Zentalis Pharmaceuticals
ZNTL
$254M
$478K 0.07%
316,550
-1,607,750
PEPG icon
40
PepGen
PEPG
$354M
$347K 0.05%
75,000
-165,000
IBIO icon
41
iBio
IBIO
$56M
$310K 0.04%
375,000
ADGM
42
Adagio Medical Holdings
ADGM
$18.6M
$215K 0.03%
110,571
ANIK icon
43
Anika Therapeutics
ANIK
$138M
– –
-588,797
CRGX
44
DELISTED
CARGO Therapeutics
CRGX
– –
-666,503
DNA icon
45
Ginkgo Bioworks
DNA
$597M
– –
-500,000
ELEV
46
DELISTED
Elevation Oncology
ELEV
– –
-1,442,061
EPIX
47
DELISTED
ESSA Pharma
EPIX
– –
-2,209,998
RCEL icon
48
Avita Medical
RCEL
$107M
– –
-389,519
TARA icon
49
Protara Therapeutics
TARA
$265M
– –
-855,000
VIGL
50
DELISTED
Vigil Neuroscience
VIGL
– –
-1,000,000
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