Opaleye Management’s Lyell Immunopharma LYEL Stock Holding History

Opaleye Management’s Portfolio LYEL Stock Details LYEL Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$1.59M	Buy	+79,097	New	+$1.85M	0.21%	46
2024 Q4	–	Sell	-69,750	Closed	-$1.93M	–	46
2024 Q3	$1.93M	Sell	69,750 -13,750	-16%	-$404K	0.32%	35
2024 Q2	$2.42M	Sell	83,500 -84,250	-50%	-$4.01M	0.55%	41
2024 Q1	$7.48M	Buy	+167,750	New	+$7.18M	1.63%	19

Other funds holding LYEL

Arch Venture Management Chicago, Illinois $677M AUM 322.07% 1-Year Est. Return

GSK plc London $599M AUM

Foresite Capital Management IV Larkspur, California $237M AUM 107.53% 1-Year Est. Return

Orland Properties Ltd Road Town, Tortola, British Virgin Islands $267M AUM 5.05% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Decheng Capital Menlo Park, California $661M AUM 299.97% 1-Year Est. Return

Almitas Capital Santa Monica, California $443M AUM 42.36% 1-Year Est. Return

Foresite Capital Management V Larkspur, California $271M AUM 309.87% 1-Year Est. Return

Millennium Management

Millennium Management New York $134B AUM 35.51% 1-Year Est. Return

Citadel Advisors

Citadel Advisors Miami, Florida $141B AUM 30.34% 1-Year Est. Return