Jane Street’s Spruce Biosciences SPRB Stock Holding History

Jane Street’s Portfolio SPRB Stock Details SPRB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q3	$367K	Buy	+7,549	New	+$382K	﹤0.01%	8720
2025 Q2	–	Sell	-499	Closed	-$10.9K	–	11353
2025 Q1	$10.9K	Buy	+499	New	+$13.9K	﹤0.01%	9196
2024 Q4	–	Sell	-209	Closed	-$7.44K	–	10884
2024 Q3	$7.44K	Sell	209 -202	-49%	-$7.4K	﹤0.01%	9377
2024 Q2	$16K	Sell	411 -636	-61%	-$34.1K	﹤0.01%	9061
2024 Q1	$61.7K	Buy	+1,047	New	+$266K	﹤0.01%	8692
2022 Q1	–	Sell	-479	Closed	-$160K	–	11168
2021 Q4	$160K	Buy	+479	New	+$143K	﹤0.01%	8966

Other funds holding SPRB

ACM

AIGH Capital Management Baltimore, Maryland $992M AUM 516.32% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.76T AUM

Geode Capital Management Boston, Massachusetts $1.92T AUM 36.1% 1-Year Est. Return

State Street Boston, Massachusetts $3.44T AUM 36.12% 1-Year Est. Return

Carlyle Group Washington, District of Columbia $8.36B AUM 14.46% 1-Year Est. Return

Quinn Opportunity Partners Charlottesville, Virginia $1.85B AUM 1.27% 1-Year Est. Return

DMKJ

David M. Knott Jr $183M AUM 73.23% 1-Year Est. Return

Vanguard Fiduciary Trust Malvern, Pennsylvania $463B AUM

Vanguard Portfolio Management Malvern, Pennsylvania $2.21T AUM

Persistent Asset Partners Hong Kong $362M AUM 191.92% 1-Year Est. Return

Jane Street's SPRB Position: Q3 2026 in Review

Jane Street opened a new position in Spruce Biosciences (SPRB) in Q3 2026: 7,549 shares worth $367K. The stake represents ﹤0.01% of the portfolio and ranks #8720 among its holdings. This is a return to the name: Jane Street previously reported a position in SPRB as recently as Q1 2025.

Jane Street first reported a position in SPRB in Q4 2021 and has held it in 6 quarters since. 40 funds tracked by Wall St. Rank hold SPRB as of Q3 2026.

Jane Street held 7,549 shares of Spruce Biosciences worth $367K as of Q3 2026.
Spruce Biosciences was a new Jane Street position in Q3 2026.
Spruce Biosciences made up ﹤0.01% of Jane Street's portfolio in Q3 2026, its #8720 holding.
Jane Street first reported a position in Spruce Biosciences in Q4 2021 and has held it in 6 quarters since.
40 funds tracked by Wall St. Rank held Spruce Biosciences as of Q3 2026.

Based on Jane Street's 13F filing for Q3 2026, filed 12 Nov 2026.